Nickel Serum Concentrations,IL-6,IL-10 Changes And Relationship In Patients Who Underwent Transcatheter Closure For Congenital Heart Disease

Objective:To observe the nickel serum concentrations changes in patients with congenital heat disease after transcatheter closure and research the relationship between nickel serum concentrations and inflammatory factor(IL-6, IL-10)in patients with congenital heat disease after transcatheter closure.Methods:30 patients with congenital heart disease(CHD)including atrial septal defect(ASD)and ventricle septal defect(VSD)have undergone transcatheter closure and 30 healthy control subjects(NC group)were selected for the study.Blood samples for analysis were collected from the patients before the closure and 24 h,1 month,3 month,and 6 month after the closure respectively. Nickel serum concentrations and IL-6,IL-10 were assayed in patients.Results:(1)Mean baseline nickel serum concentrations were within normal range.After occluder implantation,nickel serum concentrations increased over the first month and then decreased to preimplantation levels within 3-6 months. The nickel serum concentrations after occluder implantation was 3-fold higher than baseline(p＜0.05).(2)Before transcatheter closure,the IL-6 was significant higher than those in NC group(P＜0.05).After occluder implantation,IL-6 increased over the first month and then decreased to NC group levels within 3-6 months.(3)Before transcatheter closure,the IL-10 was also higher than those in NC group(P＜0.05).After occluder implantation,IL-10 increased over the first month and then decreased to NC group levels within 3-6 months.(4)The relationship between nickel serum concentrations and IL-6,IL-10 was linear correlation in 1 month after occluder implantation.Conclusions:After occluder implantation,nickel serum concentrations increased over the first month and then decreased to preimplantation levels within 3-6 months.Mean baseline nickel serum concentrations were within normal range.Nickel serum concentrations and immunity activation condition was linear correlation in 1 month after occluder implantation.