| Objective: To observe the effects of Puerarin on adhesion, invasion and migration of HO-8910 cells in vitro, and discuss its possible mechanism. Methods: MTT assay, cell-Matrigel adhesion assay, Transwell Matrigel invasion assay, Transwell motility assay and PCR assay were used to test the effects of Puerarin on adhesion, invasion and migration of HO-8910 cells. Results: The expression of ERs in HO-8910 cells was tested. Puerarin can significantly inhibit the adhesive, invasive and migratory capacity of HO-8910 cells in vitro for 12 h. The invasive activity and the migratory activity of the cells treated with E2 and Puerarin were effectively inhibited in comparison with those treated with only E2. Conclusion: Puerarin can inhibit adhesion, invasion and migration of HO-8910 cells in vitro. Puerarin can antagonize the estrogen's stimulating activities to the tumor cells.
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