The Clinical Analysis Of Fluid Sequestration In Severe Acute Pancreatitis

Objective:To analysis fluid sequestration in severe acute pancreatitis(SAP). Methods:A retrospective review was conducted of 53 patients with SAP between January 1995 and January 2000.According to the outcomes,the patients was divided into early death group,later death group and survival group.Fluid intake,fluid output and fluid sequestration were measured within initial 72 hours in the three groups. Results:Fluid sequestration in the early death group and later death group lasted for 48 hours or more.The mean fluid sequestration within initial 48 hours in the three groups was 10078.3±1616.2ml,6124.4±1081.1ml and 4719.7±1397.7ml,respectively. These changes were statistically different(p＜0.05).Six patients died of cardiac arrest and respiratory failure in the early death group,and twelve died of infection in the later death group.Conclusions:The essence of fluid sequestration is pathological redistribution of extracellular fluid and expanding of extracellular fluid volum.A large amount of fluid storages acutely in interstitial space causes cell swelling and tissue edema,may result in fatal influence on cardic and pulmonary function in the early stage,and may add to the chance of infection in the latter period.