Clinical Observation On Intravenous Lidocaine Suppresses Fentanyl-Induced Coughing

Objective:To observe the effect of prophylactic intravenous administration of lidocaine against Fentannyl induced coughing during anesthesia induction.Methods: sixty-four patients of ASA physical statusⅠandⅡscheduled for elective surgery were randomly allocated to one of four groups of sixteen patients.Each to receive either lidocaine 1.5mg/kg or placebo(0.9%saline)before the administration of fentanyl 3μg/kg or 5μg/kg.Coughs classified as coughing and graded as mild,moderate,or severe and were observed.Results:Intravenous lidocaine 1.5mg/kg,when administered before fentanyl(3μg/kg or 5μg/kg),is significantly effective in suppressing fentanyl-induced cough compared to placebao(P＜0.05).Conclusion:The prophylactic injection of lidocaine is efficiently in attenuating fentanyl-induced cough rate during anesthesia induction.