Expression And Significance Of C-erbB-2 And TopoⅡα In Breast Cancer

Objective:To evaluate the clinicopathological significance of expressions of C-erbB-2(human epidermal growth factor receptor 2 HER2),TopoⅡα(DNA topoisomeraseⅡα)in breast cancer,Methods:72 specimens were randomly selected for Affiliated Cancer Hospital of Xing jiang Medical University in January,2005～in December,2005 the breast cancer paraffin specimen and randomly selected and admitted the same period of benign breast disease were 18 cases of control,were studied by immunohistochemical technique.Results:The total expression rate of C-erbB-2 between benign breast disease and breast cancer was 5.6%(1/18)and 29.2%(21/72)respectively, and the difference was significant(X~2=90.0,P＜0.05)).The single expression of TopoⅡαin BBD and breast cancer was 0.0%(0/18),59.7%(43/72)and the difference was significant(X~2=90.0,P＜0.05),The expressions of C-erbB-2,was positively correlated with lymph node metastases and both ER(+)and PR(+)(P＜0.05),but was not related to age,tumor size,linical stage and pathological types(P＜0.05).The expressions of TopoⅡα, was positively correlated with both ER(+)and PR(+)breast cancer tissues and clinical stage(P＜0.05),but was not related to age,tumor size,lymph node metastases and pathological types(P＜0.05).the co-expression of C-erbB-2 with TopoⅡαwas positively correlated with lymph node metastases and both ER(+)and PR(+)(P＜0.05),But was not related to age,tumor size,linical stage and pathological types(P＜0.05) Conclusions:The results suggested that C-erbB-2 can be effective markers for estimating the prognosis of breast cancer.The expressions of TopoⅡαmay be useful in predicting prognosis and leading chemotherapy.