| Areneria Kensuensis VarOvatipetala Tsui also names Herb arenariae, which is wild altiplano plant.It is caryophyllaceae sandwort and perennation cushionl herb. Also it grows at 4000-500m above the sea level in alpine meadow and swallet. The height of the plant is just 4-5cm, and its main root is strong while the bottom rootlet is diligency. The shape of its leaf is acicular and the length is 1-2cm.Also the diameter of the cushion body achieve at 15-20cm around. Branches and leaves compress at low leaves. The colour of the flower is white either pink and it is seed multiplication. Herb arenariae distributes abroad Qinghai Tibet plateau and the reaource is quite abundant. It is a sort of traditional Tibetan drugs and can be used as herb medicine. Its nature and flavour is sweet-cold and its functions are cleaning heat, relieving cough, decreasing blood pressure, anteing anoxia, curing every kinds of pneumonitis and lung diseases, depressing cancer and immunore gulation and so on. Now there are some reports about the Herb arenariae efficacy of anteing anoxia but there is no report of scathing function of cerebrai anoxia ischemia.. So the herb dried powders from Tibet Jinzhu pharmaceutical factory is choised. We adopt the way of pouring to feed the rats in order to observe the herbs protective function of rats cerebral ischemia reperfusion injury .The 60 Wistar rats were randomly divided into 5 groups and feed for a week:sham group,ischemie reperfusion group(I/R),low ,middle and high Herb arenariae dosage group(the dosage were 250,500,1000mg/kg).Shame group and I/R group feed the same volume saline solution. Do operations on the rats on the eighth day. Before the operation, feed them again as the last seven days. Those carotid arteries of rats were concluded for 30 min and followed by reperfusion for 120 min .Taking the brain tissue of the rats. We observe effects on biochemical criterion. The results show that ischemia-reperfusion makes cerebral serious lesion. In brain, MDA,LDH,NO,NOS and water content obviously increase compare with sham group,but SOD,GSH-Px and ATPase decrease.1 hour before occlusion of common cartid arteries, herb arenariae(250mg/kg,500mg/kg,1000mg/kg)can reduce MDA,LDH,NO,water content and NOS in brain tissue,promote SOD,GSH-Px,ATPase.We find that herb arenariae has evident effects on ischemia-reperfusion and its mechanism may be realized through free radical effectively.This results provide primary experimental foundation for herb arenariae applied to acute cerabral ischemia diseases,and new way for Chinese traditional medicine treating acute cerabral ischemia diseases.
|
PDF Full Text Request