| Objective: To explore the reasonable use of warfarin for anticoagulation in patients with cardiovascular disease. Methods: Total 86 patients at high risk of stroke received anticoagulation with warfarin. The changes of time of reaching the target international normalized ratio (INR), the maintain dosage of warfarin and the average annual rates for bleeding events and embolic events were affected by such factors as different initial dosage of warfarin. Results: Compared with the small initial dosage (1.5mg/d) of warfarin group, the common initial dosage (3mg/d) of warfarin group reached the target INR and the stable INR with shorter time (p＜0.01,respectively), and tended to decrease the rate of embolic. Conclusion: It is better to anticoagulate with common initial dosage of warfarin in patients with cardiovascular disease.
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