Study On The Motility Of Chlamydia Trachomatis Urogenital Tract Infection

Incent years, genital tract infection with Chlamydia Trachomatisis highly prevalent in most areas of the world investigated. C.t cancanse urethritis,cervicitis,conjunctivities,pelviperitonitis,lymphogranuloma and accompanied with severe complications andsepuelaes, so the treatment of C.t infection is very important. But nowmore and more cases about resistance to antimicrobial agents have beenreported for C. t. Failures of treatments of C. t infection are often seenin clinic, which have caused the attention of many schoolars.Objective:Try to confirm the difficult of treatment for C. tgenital tract infection, by evaluating the therapy conditions ofpatients in our clinic. To evaluate strategies for C.t genitalinfection treatment and find out the relationship between manypossible factors and therapy result. Analyzing the change of negativerate and clearance rate of macrolides, tetracyclines and quinolones.Methods: 9618 C. t genital infection patients of 1998-2005 wereevaluated bacteriologically and long-term follow-up was obtained.Analyzing the change of negative rate and clearance rate ofmacrolides, tetracyclines and quinolones. Analyzing the change ofnegative rate and clearance rate ofratelevofloxacin, erythrocin, moxifloxacin, azithromycin, minocyclineand azithromtcin associated tetracycline. Many possible factors ondrug effectivenesss were evaluated such as gender, age, course ofdiseases, etc.Results:There was no diffenece between the negative rate andclearance rate of macrolides, tetracyclines and quinolones. But therewas difference between the negative rate of quinolones (P＜0.05). Thelowest is 63.8% in 2002,the hignest is 72.1%in 2003. There was nodifference between the negative rate and clearance rate oflevofloxacin, erythrocin, moxifloxacin, azithromycin, minocycline andazithromtcin associated tetracycline. The clearance rate of male andfemale is 86.2%,62.9%.Total clearance rate difference between the2 groups was statistically significant(P＜0.001).There was nodifference between ages. The clearance rate.difference between courseof disease was statistically significant(P＜0.001).The lowerst clearance rate of course was 4-6 months.Conclusion: The management of C.t genital tract infections isactually difficult. The clearance rate difference betweenmacrolides, tetracyclines and quinolones was no statisticallysignificant, but display downturn. The reason of negative ratedifference of quinolones is moxifloxacin was applied in 2003. Somefactors also have effect on the result of bacteriological eradication.The frequency of C.t eradication is apparently lower infemale; combining UU infection also reduce the clearance;the clearanceof patients with different course of disease is also different, in whichthe patients with course between 4 to 6 months are most difficult fortreatment Still, much detail remains to be worked out.