| Objective To assess protein expression levels of heparanase and basic fibroblast growth factor(bFGF) and the relation between their expression and biological factors in human colorectal cancer.Methods A total of 80 colorectal cancer and 20 normal paraffin-embedded specimens were studied by immunohistochemisty to evaluate the protein expression status of heparanase and bFGF.The relation was analyzed among the protein expression and age, sex, stage, classification, cell differentiation, invasion depth, lymphatic metastasis, vascular invasion and MVD.Results Immunohistochemistry showed that 49 specimens were heparanase positive and 52 ones were bFGF positive among 80 cancer specimens.Both human heparanase and bFGF were highly expressed in cancer cell in contrast to none expression in normal tissue . Expression was in both cytoplasm and membranous. The agreement between heparanase and bFGF expression was significant. A significant correlation was found between the expression of either protein and stage, invasion deapth, lymphatic metastasis, vascular invasion and MVD , but none in age, sex, classification, cell differentiation.Conclusion Both heparanase and bFGF were highly expressed in colorectal cancer .They may play important roles in tumor invasion, metastasis and angiogenesis. |
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