Expression Of Cyclooxygenase-2 In Wilms Tumor

Objective:To investigate the protein expression of cyclooxygenase-2(COX-2)in Wilms tumor and find the relationship between cyclooxygenase-2 expression and Wilms tumor.Methods:25 cases of Wilms tumor were studied.Ten controls were obtained from peritumor normal tissues After serial slicing to 4μm the histological slides were stained with hematoxylin and eosin,and immunostained with anti-cyclooxygenase-2 antibodies. Immunostaining was graded semiquantitatively according to the percent of stained cells with the cytoplasmic pattern of staining and according to staining intensity.Results:The positive expression rate of COX-2 was 84%in Wilms tumor and 10%in peritumor normal tissues(P＜0.001).Expression was also observed in Wilms tumor lymphaden metastasis.In comparison,cyclooxygenase-2 expression in Wilms tumor which didn't have lymphaden metastasis was less prominent.).The correlation between COX-2 expression and clinical stage of Wilms tumor was significant in statistics(r =0.966,P＜0.05).Conclusions:Cyclooxygenase-2 expression is characteristic of all Wilms tumors at all stages.Aberrant COX-2 expression may play an important role in the occurrence of Wilms tumors.