The Observation Of C-reactive Protein In Serum And C-fos Protein In Rats Brain In Status Epilepsy

Objective:As an immunity correlated disease,the development of epilepsy have close relation with cytokines.Many cytokines have been studied in exterior and interior,such as IL-1,IL-6,TNF-α.They all participate in inflammatory response,which suggest that epilepsy has relation with immunity inflammation.Cytokines which were needed to produce C-reactive protein have been founded in epilepsy.Some studies have found that C-reactive protein concentration increased obviously in epilepsy without any system infection.To study the mechanism of C-reactive protein in epilepsy,C-reactive protein concentration in serum and c-fos expression were determined in the rat lithium-pilocarpine model.Methods:32 adult male Wistar rats were divided randomly into two groups.The normal control group were injected with Sodium Chloride.The model group were administrated with LI -PI by peritoneal injection.lday,3days,7days after status epilepsy,we record the C-reactive protein concentration in serum and the c-fos expression in brain.Resuls:Compared with the normal control group,the c-fos expression in hippocampus and in cortex were significant in rats after 1day,started decreased 3days after SE,returned to basal levers 7 days after SE.Compared with the normal control group,the C-reactive protein concentration in serum changed in the same Way.The c-fos expression in hippocampus and the C-reactive protein concentration in serum were analyzed with regression analysis.P values＜0.05 were considered significant.Conclusion:During status epilepsy in rats:ⅰ,there is acute inflammatory response;ⅱ,the inflammatory response may take part in the neuron injury following status epilepsy;ⅲ,the degree of inflammatory response have been associated with the neuron injury,but additional studies are needed to determine the sure mechanism.