Clinical Research On Botulinum Toxin A Applied In Treating Lower Urinary Tract Dysfunction

Objective To evaluate the effectiveness of BTX-A injection into external urethra sphinter in treating nonrelaxing external sphincter, DESD, and dysfunctional voiding that responds poorly to baclofen or intolerant with it; into detrusor in treating female refractory OAB. Materials and methods 31 patients with neurogenic or non-neurogenic nonrelaxing external sphinter, DESD, and dysfunctional voiding that respond poorly to baclofen or intolerant with it; 3 women diagnosed as OAB with unsatisfactory results. BTX-A was dissolved in sterile, then the solution of BTX-A toxin was injected into external sphincter or into the bladder. Attention was taken pre- and post-therapeutic symptoms of voiding, UD evaluation, etc. Results The symptoms of voiding were improved after injection into sphincter or detrusor. Conclusions BTX-A injection into external sphincter is an effective method in treating spastic or nonrelaxing external sphincter; can help improve symptoms of some refractory OAB patients.