Study Of Relationship Between Coronary Artery Narrow Degree Of The Patients Underwent Coronary Angiography And Pulse Pressure

Objective To evaluate the relationship between the influence factors of coronary artery narrow degree and pulse pressure, and to evaluate the value of pulse pressure during the development of coronary artery disease, so that we can offer useful data and clues to the prevention and treatment of coronary artery disease.Methods The 268 patients were observed. All patients underwent coronary angiography. There were 212 male patients and 56 female patients, mean age (58.11±11.32) years old. All of them were measured with aortic systolic blood pressure, diastolic blood pressure, pulse pressure and mean arterial pressure. At the same time, patients preprandial was examed by routine assay, the essential hypertension history, diabetes history and smoking history were recorded. The degree of coronary artery disease was denoted with the coronary number of stenosis and the score of coronary artery stenosis. The patients were divided into the coronary artery normal group 78 examples and coronary artery disease group 190 examples by the result of coronary angiography. According to the number of suffered coronary artery, patients were divided into single-branch lesions 68 examples, double- branch lesions 56 examples and triple- branch lesions 66 examples; patients were also divided into two groups by more or less than 60 years old, and the value of pulse pressure higher or lower than 60 mmHg.Results The advanced ages, the male, smoking rate, essential hypertension prevalence rate, diabetes prevalence rate, fasting blood glucose, low density lipoprotein, systolic blood pressure, mean arterial pressure as well as pulse pressure of the coronary artery disease group are significantly higher than the coronary artery normal group. After adjustment for age, the low density lipoprotein, systolic blood pressure as well as pulse pressure are no more different in statistics (P <0.05).Furthermore using Logistic regression analysis shows : The ages, PP, the gender, the smoking as well as low density lipoprotein are the dangerous factors of coronary disease. The pulse pressure is the less important factor than ages. In different coronary disease ranges, and after adjustment for age, along with the increase of the coronary number of stenosis, the pulse pressure, low density lipoprotein, total cholesterol, diabetes prevalence rate all are increase . There were also a significant difference between the three groups(P <0.01). In the groups of age >60 years old, the systolic blood pressure, the mean arterial pressure, the pulse pressure as well as the rate of the triple- branch lesions are higher than other groups (P <0.01) . In the groups of pulse pressure >60mmHg, the systolic blood pressure, the score of coronary artery stenosis of the coronary artery disease as well as the rate of triple- branch lesions are significantly higher than the group of the pulse pressure <60mmHg (P <0.01). We chose the score of coronary artery stenosis as the dependent variable, chose every dangerous factors as the independent variables, using the bivariate correlations and partial correlation analysis. The results shown that the degree of coronary artery stenosis had positive correlation with fasting blood glucose, low density lipoprotein and pulse pressure(P <0.01). And the correlation coefficient of PP (r =0.49) was significantly higher than the correlation coefficient of other risk factors. After the multiple stepwise regression, we got that pulse pressure age and smoking were the best predictor for the severity of coronary artery stenosis, without the influence of essential hypertension history, diabetes history, blood lipid and systolic blood pressure.Conclusion Aortic pulse pressure was the most convenient parameter reflecting the elasticity of large artery, had closely correlation with the severity of coronary artery narrow degree. Aortic pulse pressure has the independent prospective value to the coronary artery disease.