Expressions Of CD44s And MUC2 Proteins In Transitional Cell Carcinoma Of Bladder And Their Clinical Significance

Objective:CD44s and MUC2 proteins are widely expressed in many tumors and the expression is considered to be associated with disease progression. In this study, we investigated whether the CD44s and MUC2 proteins would predict the pathological grades and TNM stages and number and and recurrence of transitional cell carcinoma of bladder.Methods:Immunohistochemistry was used to detect the expressions of CD44s and MUC2 proteins in 52 cases of transitional cell carcinoma of bladder (Grade I tumors was 18,Grade II tumors was 17,Grade III tumors was 17;Non-invasive tumors was 27,invasive tumors was 25)and 8 subjects of normal bladder mucosa.Results:CD44s has different level of expression in both normal bladder mucosa and transitional cell carcinoma of bladder.The positive expression of CD44s in 52 cases of transitional cell carcinoma of bladder was 22 cases(42.3%). The positive rates were correlated with pathological grades and TNM stages (P<0.05) .The expression patterns was correlated with pathological grades (P<0.05). But there was poorly significant difference between the expression of CD44s and recurrence and number of cancer(P>0.05). The expression of MUC2 was negative in all normal bladder mucosa The positive expression in 52 cases of transitional cell carcinoma of bladder was 23 cases(44.2%). There was poorly significant differenence between the expression of MUC2 and the pathological grades and different TNM stages and recurrence and number of cancer(P>0.05).In positive expression of MUC2 of 23 cases,the positive expression of CD44s were 6 cases,the others were negative. There is a inversely relationship between the expression of CD44s and MUC2 proteins in transitional cell carcinoma of bladder(P<0.05).Conclusions:There is a relationship between the expression of CD44s and MUC2 proteins in transitional cell carcinoma of bladder. The expression of CD44s may be a useful marker of pathological grades and TNM stages of transitional cell carcinoma of bladder, combining detection of MUC2 protein can improve the sensitivity of diagnosis.