The Study Of The Effect Of Phychophysiology On Non-erosive Reflux Disease

Objective To study the effect phychophysiology on non-erosive reflux disease by evaluating the correlation of gut hormon-motilin and phychophysiology.Methods Fourteen normal volunteers without typical reflux symptom comfirrned by endoscopy and ambulatory 24h pH monitoring and thirty NERD patients diagnosed by symptom evaluation, and combined endoscopy and ambulatory 24h pH monitoring or proton pump inhibitor treatment trial were enrolled in this study. Examed the blood plasma level of motilin(MTL) by radioimmunity(RI) method. , Evaluated the anxiety and (or) depression score of all subjects with Symptom Checklist 90 (SCL-90) and Hospital Anxiety and Depression Scale (HAD).Results Twenty-three ones of all NERD patients had abnormal motilin plasm level,accounted 76.7%, but the normal control only three ones, accounted 21.4% (P<0.01) ; SCL-90 score: The scores of most items of each mental scale were significantly higher in the NERD patients than in the normal controls, but there was no correlation between the degree of mental score and the level of motilin. HAD evaluation: Thirteen ones of NERD patients suffered from different degree anxiety and(or) depression,accounted 43.3%, About the normal controls, only one was light degree depression,accouted 7.1% (P<0.05) . The difference of abnormal rate between motilin and the HAD evaluation existed statistical significance (P<0.01) .Conclusion Our findings suggest that different degree phychophysiological factors may lead to the symptomatic appearance of part NERD patients, which may be a risk factor of NERD by effecting secretion of gut hormone through the braingut reflect way.