The Clinical Study Of The Effect Of 7.5% Hypertonic Saline On The Treatment Of Intracranial Hypertension

Objective:The study was undertaken to evaluate the effect of 7.5% hypertonic saline (HS) on the treatment of intracranial hypertension with a intracranial pressure monitor, so as to offer reference for the treatment of intracranial hypertension.Methods:Based on the prospective study of the 29 cerebral hemorrhage cases who were operated on in department of neurosurgery of the first affiliated hospital of jinan university from April 2006 to March 2007. We divided randomly these cases into two groups according to hospital admission time, the control group conceived mannitol therapy, the therapy group conceived alternating hypertonic saline and mannitol therapy. We measured serum osmolarity, sodium and chloride every day after operation. And monitored the change of intracranial pressure and blood pressure after every treatment of intracranial hypertension. Then we compared the difference of serum osmolarity, sodium and chloride after therapy by the method of the T test. And compared the effect, efficiency and persistence time on dropping ICP of hypertonic saline and mannitol in therapy group by the method of the T test. And compared the difference of the decrease percent and value of ICP of hypertonic saline between the peak and not-peak time of cerebral edema, so and mannitol.Result:1 The differences of Serum osmolarity, sodium and chloride had statistical significance between the therapy group and the control group.2 The differences of the efficacy in the treatment of intracranial hypertension between hypertonic saline and mannitol were not statistical significance (P＞0.05) in therapy group. 7.5% HS caused a more quickly decrease in ICP than mannitol (p＜0.05), And caused a longer time in ICP decrease than mannitol (p＜0.05) in the therapy group.3 The decrease percent of ICP by hypertonic saline and mannitol in the peak time of cerebral edema were lower than in not-peak time of cerebral edema.Conclusion:The effects of hypertonic saline and mannitol are approximately in the treatment of intracranial hypertension. It is significant to go deep into search hypertonic saline combining with mannitol for the treatment of intracranial hypertension.