Exploration On Correlation Factors Of Bone Mass Changes In Systemic Lupus Erythematosus Patients

Objective: To explore the correlation factors and major correlation factors which affect thebone mass changes by measuring the bone mass of systemic lupus erythematosns patients usingdual energy X-ray absorptiomenty (DXA).Methods: (1) We investigated thirty-one systemic lupus erythematosus female patientsexcluding those in the critique, gestation and lactation period (45 year old with the average age24.68±7.92y) using the retrospective study. (2) The bone density of the orthotopic lumbarvertebrae (L1-L4) and proximal ends of both femurs was measured using DXA. The criterionof the decrease in bone density or osteoporosis is that at least one of the above two sites has lowbone density. According to this, the patients were divided into two groups: the group with lowbone density and the group with normal bone density. (3) Forty-three possible factorsaffecting the bone density were recorded and analyzed using mono-factor analyses to explorethe correlation factors causing the changes in the bone mass. Those factors (P＜0.3) bymono-factor analyses were analyzed again using Logistic multifactor gradual regressiveanalysis to explore the major correlation factors associated with the bone mass changes in lupuserythematosus patients.Results: (1) The mono-factor analysis reveals that the following factors are statisticallycorrelated with the bone mass changes (P＜0.05): urine protein, SLEDAI, course of disease,bone gla protein (BGP), parathyroid hormone (PTH), SLICC, hormonal intake accumulatingtime, hormone accumulating dose. (2) The multiple factor Logistic multifactor gradualregressive analysis reveals that hormone accumulating dose(P=0.037) and SLICC(P=0.045)were statistically correlated with the bone mass changes of the patients (P＜0.05). Oddsratios are respectively 12.719 and 11.565. The above two indexes are major correlationfactors affecting the bone mass changes of lupus erythematosns patients.Conclusions:1. The correlation factors affecting the bone mass changes of systemic lupus erythematosuspatients are urine protein (UP), SLEDAI, course of disease, PIH, BGP, SLICC, hormonalintake accumulating time and hormone accumulating dose.2. The major correlation factors affecting the bone mass changes of systemic lupuserythematosus patients are hormone accumulating dose and SLICC.