Effect Of Purgation In Different Steamed Product Time Of Radix Polygoni Multiflori Preparata

As a precious medicinal plant, the Polygunum Mutiflomm Thunb has the effects of detoxication, cleared up the carbuncle, moistened the intestines and relaxed the bowels. The restrict Polygunum Mutiflorum Thunb as the steamed product of Polygunum Mutiflorum Thunb, it has the effects of patched Liver and Kidney, profited the blood, blacken the beard and hair and maked the physique stronger. Therefore, it were applied in apiece each health protections as a good produce. At the present time, the Anshebunaoye were appraised the good produce in the health protections market by spacious people. It bases is the restrict Polygunum Mutiflorum Thunb and Herba Epimedii et al. There are the effects ofnourish the brain relieve anxiety,reinforcing kidney and spermatogenesis,replenishing qi and blood and it using in neurasthenic, insomnia, bad memory, swirl, lack power. Because used it long time, it has dry intestines and costive as side effect by feedback information of sufferers. The issue is that the braise time of Polygunum Mutiflorum Thunb for as a mostly medicine if the braise time shorter, lacked the restoration dements, the effect of rush down was strong, otherwise the braise time longer, the restoration elements increased, the effect of constipation is boost up. It was researched different brasie time of Polygunum Mutiflorum Thunb for the infection and mechanism of rush down effect by the colorimetry of magnesium acetate, administration the mixture of carbon powder and different Polygunum Mutiflorum Thunb, pusheing the ink in small intestine et al..Through the experiment we can concluded the hereinafter results:(1) With the braise time prolong, the rush down effect of union anthraquinone gradually decreased, and free anthraquinone increased at the same time.(2) The experiment of defecation in mice indicated that the grain number of the crude Polygunum Mutiflorum increased comparative to normal saline group, and the dejection watery and mild even no shaped. But the dejection water content obviously bellower than the steamed time group of 0h,2h.(3) The experiment of the small intestinal propulsion in mice in vivo indicated that the comparative is no distinctness diversity between the steamed time of group 0h,2h,4h,6h,8h,10h and the group of normal saline. For the wet weight of the mice small intestinal, we can concluded the same result.(4) The experiment of the colon propulsion in rat in vivo indicated that the comparative is obviously diversity (P＜0.001 ) between the crude Polygunum Mutiflorum group and the group of normal saline. The braised time of group 0h,2h comparative to the normal saline is obviously diversity (P＜0.01). But the steamed time of group 4h,6h,8h,10h comparative to the normal saline is no diversity.(5) The experiment of the shrinking intestines in rabbit out of vivo indicated that the crude Polygunum Mutiflorum group and the steamed time of group 0h,2h has the restrain effect for small intestine out of vivo. It comparative to normal saline group is obviously diversity (P＜0.001). The steamed time of group 4h comparative to the normal saline group has diversity obviously (P＜0.05). But for shrink strain, the steamed time of group 6h,8h,10h comparative to the normal saline group has no diversity.(6) The result that the Polygunum Mutiflorum Thunb for gut out of vivo indicated that the crude Polygunum Mutiflorum can antagonism the gut excitation effect by Aeetyl choline, chlorate barium. The main behave is tonicity decline, amplitude decline and lower. But for tab gut more laxation and amplitude more decline by atropin and adrenalin. The inhibition has distinctness diversity (P＜0.001) by simple atropin and adrenalin.The result of those experiment indicated us:(1) The purgative effect ofPolygunum Mutiflorum Thunb significantly decreased with the different steamed time and 4h of Polygunum Mutiflorum Thunb is the best.(2) The action mechanism of Polygunum Mutiflorum Thunb is likely to the action effect of it for M receptor andβ₂ receptor of gut smooth muscle out ofvivo.