Analysis Of Genetics On Type 2 Diabetes Mellitus In Korean And Han Ethnic Nationality Of Yanbian

Objective: To explore the risk of factors and hereditary feature on type 2 diabetesmellitus (T2DM) in Korean and Han ethnic nationality of Yanbian, and to providescientific basic for Korean nationality to prevent and intervent T2DM. Methods: Baseon the epidemiological survey of T2DM in urban community population of Yanbian, afrequency matched case-control study was used. Randomly drew 222 T2DM patients inYanbian as case-group and 1747 first-degree relatives. Compared with case-group, 458people having normal glucose tolerance were selected as control-group and 2261first-degree relatives. To research their nature condition, living habit, patient history,symptoms, physical symptom, twenty items laboratory examination and genealogy atlas.It was applied Falconer to estimate heretability, used Li-Mantel-Gsrt to analyzesegregation ratio, and sieved out the high risk factors of T2DM by unconditionalunivariate and multivariate Logistic regression. All collected datum were statisticallyanalyzed by data packet SPSS11.5. Results: 1. In Yanbian Korean and Han ethnicnationality, the prevalence rate of the T2DM first-degree relatives were respectively5.09% and 4.82%, significantly higher than that in control-group which were 1.64% and0.89% (P＜0.001). Prevalence relative risks (RR) were respectively raised 3.10 and4.82 times. Among them, the first-degree relatives prevalence rate in Korean femalepatients (12.39) was significantly higher than that in Korean male, Han ethnicnationality (4.67, 4.85 and 4.80 respectively, P＜0.05). The first-degree relatives RR inKorean female patients were 2.6 times over than the other relationships. 2. Statisticsresults indicated the prevalence rate of T2DM was no significant difference betweenKorean and Han ethnic nationality (P=0.809, 0.056). It illustrated no nation differencein Yanbian, but having an evidently hereditary tendency. 3. In Yanbian, total prevalencerate of T2DM was 39.6±0.006; Prevalence rate of Korean and Han ethnic nationalitywere 39.4±0.39 and 51.6±0.006 respectively. Han ethnic nationality was higher than Korean nationality, but no significant difference. The first-degree relatives prevalencerate in Korean female (76.4±0.07) was significantly higher than that in male(37.2±0.523, P＜0.001). It pointed out that the first-degree relatives' prevalence rate ofT2DM in Korean female had a hereditary liability than other people. 4. The segregationratio of T2DM in Korean and Han ethnic nationality of Yanbian were 0.21 and 0.15,which were lower than 0.25, and not meet the features of single gene inheritance disease,and support the character of polygenic diseases. 5. Family history of T2DM,hypertension, waist-to-hip ratio (WHR), intake Of sweet food were the major risk factorsof T2DM. Conclusions: It was obviously hereditary tendency for T2DM in YanbianKorean and Han ethnic nationality having the charater of polygenic diseases, Koreanfemale first-degree relatives had a high hereditary liability. Family histories of T2DM,hypertension, WHR, intake of sweet food were the major risk factors of T2DM.