| Objective:To investigate the protective effects of ulinastatin on lung injury in patients undergoing cardiopulmonary by pass(CPB).Methods:30 ASAⅡ-ⅢPatients Who underwent elective heart surgery were divided into two groups randomly,15 patients in ulinasatin group received ulinastatin 20000 u/kg,15 patients in control group received same volume of saline instead of ulinastatin.Arterial blood samples were taken at the beginning of surgery(t1),10min after aortic release(t2),10 min(t3)and 1h(t4)after discontinuation of CPB for blood gas analysis,venous blood samples were taken at the same time far determination of plasma levels of TNF-α,IL-8.Respiratory index (PA-aDO2/PaO2)was calculated at T1-4,Arterial blood gas was checked at 1h,2h and 3h after operation and oxygenation index(OI)were monitored.Results:There were no significant different in sex,age,weight,height,duration of CPB and aortic cross-clamping time between the two groups.In group C the plasma levels of TNF-αwas significantly higher than the baseline values(T1)during and after CPB(P＜0.01),the plasma levels of TNF-αin group U was significantly lower than that in control group in 10min after aortic release(t2),10 min(t3)and 1h(t4)after discontinuation of CPB(P＜0.05).In group C the plasma levels of IL-8 was significantly higher than the baseline values(T1)during and after CPB(P＜0.01),the plasma levels of IL-8 in group U was significantly lower than that in control group in t2,t3 andtn(P＜0.05).The respiratory index(RI)in control group was significantly higher than the baseline values(T1)during and after CPB(P＜0.01),The respiratory index in group U was significantly lower than that in control group in t2,t3 andt4(P＜0.05).The oxygenation index(OI)in control group was significantly higher than the baseline values(T1)during and after CPB(P＜0.05), The oxygenation index in group U was significantly lower than that in control group in t2t3 andt4(P＜0.05).Condusion:Our results show that ulinastatin can effectively adjust the balance between Pro-and anti- inflammatory cytokines and protect respiratory function. |
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