The Study Of The Resting Heart Rate And High Sensitivity C Reactive Protein, Endothel, Target Organ Damage In Patients With Essential Hypertension

Aim To study the correlation of resting heart rate(RHR)and high sensitivity C reactive protein(hs-CRP),endothel(ET),the markers of target organ damage[such as left ventricle ejection fraction(LVEF),left ventricular mass index(LVMI),microamount albumin of urine (MAU),endogenous creatinine clearance rate(Ccr)]in patients with essential hypertension and search for the possible mechanisms.Methods 192 patients,including 104 men and 88 women,have been diagnosed exactly as essential hypertension.All these patients had been divided into 3 groups in accordance with RHR:RHR₁≤69bpm,70bpm≤RHR₂≤79bpm,RHR₃≥80bpm,and fasting plasma glucose (FPG),blood-grease[Triglyceride(TG),total cholesterol(TC)],hs-CRP,fibrinogen (Fib),ET-1,white blood cell(WBC)count,LVEF,LVMIwere performed.The examined results of different groups' made contrast and correlation each other.Results(1)The comparison between RHR and blood pressure,sugar and grease metabolism:In RHR₃ SBP had statistical significance compared with the above markers in RHR₁, RHR₂,In RHR₂ and RHR₃,TC had statistical significance compared with the above markers in RHR₁.In RHR₃,FPG had statistical significance compared with the above markers in RHR₁ TG had statistical significance in these respective groups(P＜0.05 or P＜0.001).Correlation analysis showed that SBP,FPG,TG correlated positively to RHR,their correlation coefficient r = 0.750,0.414,0.162 respectively(P＜0.001 or P＜0.05).(2)The comparison between RHR and hs-CRP,Fib,ET-1,WBC count:hs-CRP,ET-1 had statistical significance in these respective groups(P＜0.01).In RHR₃ and RHR₂,Fib had statistical significance compared with the above markers in RHR₁,Correlation analysis showed that hs-CRP,Fib,ET-1 correlated positively to RHR,their correlation coefficient r=0.390,0.315,0.661 respectively(P＜0.001);WBC count was not distinguished different(P＞0.05).(3)RHR of the hypertensive patients' with high blood sugar had faster resting heart rate than the RHR of the hypertensive patients' without high blood sugar.The two groups had statistical significance(P＜0.05).(4)The comparison between RHR and target organ damage:LVMI,LVMI MAU,Ccr had statistical significance in these respective groups(all P＜0.01).LVMI,MAU increased with the RHR,Correlation analysis showed that LVMI,MAU correlated positively to RHR,their correlation coefficient r =0.556,0.576 respectively(all P＜0.01);and LVEF,Ccr decreased with the RHR,LVEF,Ccr correlated negatively to RHR,their correlation coefficient r =-0.632,-0.510(all P＜0.01). Conclusion:The RHR of the patients with essential hypertension were fast,and RHR was correlated to the level of blood pressure,the metabolism of sugar and grease,hs-CRP, ET-1,target organ damage.The fast RHR may have the relations with autonomic imbalance of the sympathetic system.RHR may be the independent risk factor of essential hypertension.