Association Between Toll Like Receptor 4 Polymorphism And Acute Pancreatitis

Recently the clinical research discovered the Toll-like receptor 4 widly existed inside and outside the secretion department of pancreatic gland organization. Toll-like receptor 4 fourth exon of a missense mutation (896A>G) can damage receptor ligand recognition ability to affect the immune system's defensive reaction. But individual gene polymorphism and disease phenotype diversity and susceptibility was related. Then Toll-like receptor 4 mutations affects the development and the prognosis of acute pancreatitis? Objective: To determine the relationship between the mutations and AP. Methods: TLR4 896A>G mutation was surveyed by mispairing PCR-restriction fragment-length polymorphism analysis technique in AP pantents and healthy volunteers. Results:â‘ All individuals with Toll like receptor 4 mutations were heterozygous for the Toll like receptor 4(896A>G);â‘¡The allele frequency of the TLR 4(896A>G)was 5.7% among 53 healthy volunteers, 10% among mild acute pancreatitis patients, 9.9% among severe acute pancreatitis (SAP) patients;â‘¢Compared with healthy volunteers, the significant difference was found in infection of pancreatic necrosis in SAP patients; Compared with SAP patients without pancreatic necrosis, the allele frequency of the TLR 4(896A>G) rise significantly. Conclusions: human TLR4(896A>G) mutations have the bidirectional role in the pathogenesis of;â‘ protection function in the early stage of; (2) risk factor in the later stage of AP.