Study On Nonalcoholic Fatty Liver With Different Therapeutic Principles

Objective:This research aims to observe the therapeutic use of Traditional Chinese medicine with different therapeutic principles to NAFL, Such four methods as transforming phlegm and dispelling dampness, quickening the blood and transforming the stasis, coursing liver and detoxifying toxins and invigorate the spleen and dispersing food as well were applied to prevent and treat rats and patients, to discuss its mechanism and clinical efficacy.Method:1,clinical study: By the way of prospective randomly controlled study, we chose 150 patients who were divided into 5 groups, 30for each group. The therapeutic groups:①the group of transforming phlegm and dispelling dampness②the group of quickening the blood and transforming the stasis③the group of coursing liver and detoxifying toxins and④the group of invigorate the spleen and dispersing food. The control group:yi shah fu oral. 3 months later, clinical manifestation,liver function,blood lipid,the levels of SOD and MDA inblood and the B-ultrasound were observed to evaluation its clinical effect. 2,experiment study:Fed the rats with feed stuff rich in fat to reproduce the animal models with fatty livers, and observe the levels of fat in the livers, serum liver function and the levels of serum fat, the content of SOD, MDA inthe liver tissues, the membrane fluidity of the mitochondra of the hepatic cells as well as the pathological changes happened in the liver tissues. Such four methods as transforming phlegm and dispelling dampness, quickening the blood and transforming the stasis, coursing liver and detoxifying toxins and invigorate the spleen and dispersing food as well were applied to prevent and treat the rats with fatty livers and the influence of the four therapeutic methods on the markers mentioned above was observed.Result: 1,clinical result:①each group can improve liver function and inflammation (P＜0.01或P＜0.05);after the treatment, in regard of improving liver function, compared with the control group, the group of quickening the blood and transforming the stasis, the group of coursing liver and detoxifying toxins and the group of invigorate the spleen and dispersing food had obvious defference (P＜0.01或P＜0.05)②the group of quickening the blood and transforming the stasis and the group of invigorate the spleen and dispersing food can decrease blood lipids (P＜0.05)③each group can increase the activity SOD, decrease content of MDA (P＜0.01或P＜0.05), after the treatment, compared with the control group, the group of quickening the blood and transforming the stasis, the group of coursing liver and detoxifying toxins and the group of invigorate the spleen and dispersing food had obvious defference (P＜0.01 P＜0.05)④after the treatment, in regard of improving clinical manifestation and B-ultrasound, compared with the normal control group, the group of quickening the blood and transforming the stasis and the group of invigorate the spleen and dispersing food had obvious defference (P＜0.05).2,experiment result: Liver function was significantly improved in each group (P＜0.05 or 0.01);quickening the blood and transforming the stasis, invigorate the spleen and dispersing food could decrease the levels of serum fat and the levels of fat in the livers, the range of fatty degeneration of hepatic cells and alleviate the inflammation of the livers (P＜0.05 or 0.01), simultaneously lower the content of MDA, strengthen the activity of SOD and the membrane fluidity of the mitochondria of the livers (P＜0.05 or 0.01);the method of coursing the liver and detoxifying the toxins could lower the content of MDA, strengthen the activity of SOD and the membrane fluidity of the mitochondria of the livers (P＜0.05), but could not affect the levels of serum fat and the levels of fat in the livers (P＞0.05).Conclusion: Every therapeutics can clear free radicals, strengthen the ability of antioxidation, regulate and improve the imbalance of free radicals and as a result prevent and treat fatty degeneration and the inflammation of the liver. As a whole, quickening the blood and transforming the stasis is the best method to treat NAFLD in this experiment, invigorate the spleen and dispersing food has the reasonable action as quickening the blood and transforming the stasis on reducing blood lipids and improving liver function. Coursing liver and detoxifying toxins has the proper action on improving liver function, transforming phlegm and dispelling dampness is the worst method.