| [Objective]In recent years, the incidence of diabetes is increasing year by year,and it has already become one of the main diseases of endangering our health.Through the whole course of occurrence and development on type 2 diabetesmellitus, insulin resistance (IR) carry throughout. IR is the importantetiopathogenisis and characteristic of T2DM, and it is also the pathologicfoundations of various chronic T2DM complications. To investigate the chineseincidence and to find out the curative medicine for IR become the hot spotof Chinese Medicine in treating T2DM. My tutor-Professor LiQun Zhu has usedQi-reinforcing and Yin nourishing,Blood activating Chinese Medicine withwestern medicine to treat patients of latent autoimune diabetes inadults(LADA), and he found out that the used method can improved Langerhans'islits B cell function. The purpose of this research is to observe and provethe use of Qi-reinforcing and Yin nourishing,Blood activating Chinese Medicinein improving the IR state of T2DM patients with IR, and to offer a new wayof thinking and treatment in order to lower the incidence and death rate ofDM and its complication.[Method]According the WHO diagnose and traditional Chinese Medicine dialecticalstandard, 90 T2DM with IR patients from the in-and-out patient endocrinologydepartment in the Chinese medical hospital of GuangDong Province from Octoberof 2005 to October of 2006 were chosen with the respect of seeing time. These selected patients were randomly divided into 3 groups(Group A, B, C).On thebasis of 2 weeks foundational diabetic treatment, Group A was givenbiguanides(30 patients, 3 patients dropped out); Group B was givengQi-reinforcing and Yin nourishing,Blood activating Chinese Medicine(30patients, 2 patients dropped out); Group C received the combined treatmentsof Group A and B(30 patients, 4 patients dropped out).The treatment wasconsisted of 3 months. The sex,age,patients' condictions,length of diseasetime were measured statistically, and there was no apparent difference(P＞0,05), which meant comparison could be taken. The results of clinicalsyndromes,fasting plasma glucose(FPG),2h plasma glucose (2hPG),glycosylatedhemoglobin(HbAlc),fasting insulin(FINS),blood coagulation,blood fat weremeasured through the course of experiment, and IR index was calculated (Homa-IR=FPG×FINS/22.5. FINS unit is mu/L, FPG unit is mmol/L).And we also observedthe differences of the safety indexes, like bisic body check,3 regularities,liver and kidney function,electrical cardiogram, before and after thetreatment.[Results]After 3 months of treatment, Clinical symptom, FPG,2hPG,FINS,HbAlc,HOMA-IR, blood fat, blood coagulation had varied level of drastic improvement(P＜0.01).In the area of improving clinical syndromes, lowering FINS,bloodcoagulation,blood fat, Group C showed the best results, Group B was slightlypoor than C, and Group A was the least improved. On the other hand, in loweringFPG,2hPG and HbAlc, Group C was the most effective, and Group A and B showedno apparent difference. The safety indexes demonstrated no evident differencesbefore and after the treatment, and no adverse side effects were reported.[Conclusion]Qi-yi deficiency and blood stasis are the main incidences for developingtype 2 DM and its complications; when blood glucose rises, the blood fat andblood coagulation show changes, and with longer period of disease time, thechanges would be greater; qi-reinforcing and yin nourishing,blood activatingchinese medicine can improve the syndromes of qi-yin deficiency and bloodstasis type DM patients, lower blood glucose, improve IR,blood fat and bloodcoagulation; though the power of qi-reinforcing and yin nourishing,bloodactivating chinese medicine in lowering blood glucose is less effective thanbiguanides, it can improve IR with the same strength as using biguanides(P ＞0.05). If the above two types of medicine are use together, the curativeeffect would better. When the method was used clinically, no adverse effectwas reported. Therefore, the clinical use of qi-reinforcing and yin nourishing,blood activating chinese medicine is safe.
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