Experimental And Clinical Research Of Treatment Of Dental Fluorosis By Teeth Bleaching Gel

Dental fluorosis is the period of tooth development mineralized body excessive fluoride intake caused by a special enamel hypoplasia. Chronic is endemic fluorosis an outstanding performance. Light persons deprived of the normal tooth surface sheen, there opaque patches, severe tooth convey yellow, tan or brown, directly affect the appearance, the patients teeth pressing for the restoration of the natural sheen.Dental fluorosis bleach treatment is still a medical problem. For a long time, the dentist for dental fluorosis used photocurable resin veneers or porcelain crown. They have the short course, the advantages of quick, moderate and severe dental fluorosis. particular type of enamel defects dental fluorosis results significantly. But these technologies have the potential to produce some complications, and the dental tissue injury is greater. From a medical principles and the long-term health of patients, and using technology to improve bleach patients more conducive to the resumption of the natural color of teeth, dental and periodontal health.Dental fluorosis in China's high incidence of seriously affected patients appearance. With the improvement of material and cultural level, the requirements of the decolorization beauty more and more patients. Now commonly used for bleaching agent hydrogen peroxide. Hydrogen peroxide is a strong oxidant properties of instability, effective short time. Imports bleach for carbamide peroxide, bleach principle is carbamide peroxide decomposition of hydrogen peroxide role. Carbamide peroxide decomposition, not only produce hydrogen peroxide, also produced urea, ammonia, carbon dioxide and other harmful substances. Carbamide peroxide domestic product quality to ensure that imported products expensive.ObjectiveThis study aims to develop a suitable family with the safe, efficient, convenient and inexpensive teeth bleaching agents.Materials and Methods1. Hydrogen peroxide solution by adding different concentrations of stabilizer, by hydrogen peroxide catalyst o-phenylenediamine horseradish peroxidase reaction, and absorbance detection microplate reader, indirect observation and comparison of different concentrations stabilizer after hydrogen peroxide attenuation speed. Determine the stability of a best concentration.2. Choice of hydrogen peroxide as the main raw material, adding proper stabilizer, glycerin, reprocessing starch, Carbopol plastic, after appropriate processing, and turn them into paste, put teeth bleaching gel clinical usage than 40 times and 20 times the amount of guinea pigs for acute toxicity testing, stimulation test, allergic reaction test, the oral mucosa caused by changes in the body and animal situation.3. Collection of dental fluorosis patients three hundred cases, only a difference, lateral incisor and canine, according to their color depth into light, medium, 3 groups, namely 35,29,26-tooth surface, Observation tooth bleaching gel for different levels of dental fluorosis therapeutic effect.4. SPSS 10.0 software applications using single-factor analysis of variance, correlation and regression analysis, x 2 test. Europium 0.05 to obtain significant test standards.Results1.4 kinds solution preparation, the day the group result was no significant difference (P> 0.05). With the extension of storage time, the Group results were to shrink, but to varying degrees. Stabilizer higher levels decreased slowly, the 120 day A, B, C and D group was dropped 20.3%, respectively. 38.6%,45.8%,60.7%. The results suggest the H2 02 stabilizers have a stabilizing effect, the role of strength and stability dose was positively correlated. 2. Toxicity test results : higher tooth bleaching low dose group and matrix group of animals mouth, jets and esophageal mucosa compared with the control group had no abnormal reaction, histological examination showed the animal heart, liver, spleen, lung, kidney, esophageal, oral mucosa, have no morphology.3. Stimulation test results : teeth bleaching gel matrix group and the control group of animals oral mucosa and submucosal esophageal squamous no irritation.4. Allergy Test Results : Test results show the use of tooth bleaching gel group no delayed-type hypersensitivity occurred.5. Clinical results :Teeth bleaching gel for different degrees of dental fluorosis different cure rate. Slightly higher than the moderate, severe,Moderately severe than P<0.001, Plastic teeth bleaching treatment of mild, moderate and severe dental fluorosis the efficiency difference was not significant. P=0.789>0.05ConclusionThe preparation efficacy stable and easy to use, low cost and suitable for use with the family. My dental fluorosis high incidence of the need for many patients, teeth bleaching gel has a broad application prospects.