Vitamin E Supplementation Links To Oxidative Stress In Chronic Renal Failure

Objective: To investigate the influence of vitamin E therapy on oxidative stress in patients undergoing chronic renal failure (CRF).For this study, we contrast normal control, treatment group and control group of oxidative stress markers. To explore if oxidative stress state exist in CRF; also to explore the influence of vitamin E therapy on oxidative stress in CRF.Methods: 40 CRF patients were randomly divided into treatment group (n=20) and control group (20). Twenty healthy volunteers were as normal control. Treatment group treated by vitamin E 600mg/d for 8 weeks. These oxidative stress markers included plasma malondialdehyde (MDA), Glutathione (GSH), vitamin E (VE) were measured at the beginning and the end of the study. All data was analyzed by statistic software SPSS11.5.Results:①: At baseline, the level of Plasma MDA was significantly higher in CRF compared with those in healthy subjects (p<0.01). The levels of plasma GSH and VE were lower than these of in healthy subjects (p<0.01) before study.②: After eight-week observation period, MDA level was lower in treatment group, GSH and VE levels were significantly higher in treatment group than before eight-week observation period. GSH and VE levels were significantly higher in treatment group than control group.Conclusion:①Oxidative stress in CRF is higher than that in normal control.②Vitamin E supplementation may alleviate the oxidative stress of CRF. To guess mechanism, VE is not only scav of superoxide anion and singlet oxygen, but also blocking agent of lipid peroxidation. At the same time, VE could reduce IL-6 and CRP through suppressing phagocytic cell in path of NF-κB. Therefore, if we could control oxidative stress, we would correct the complication of CRF.