The Intervention Research On The Alcoholic Liver Disease By Qingkailing Injection Together With QingReHuaShi And JieJiu Decoction

The alcoholic liver disease (ALD) is toxic liver harm induced by drinking massively long-term, which including alcoholic fatty liver (AFL), alcoholic hepatitis (AH) and alcoholic liver cirrhosis (ALC). ALD is a important cause of a disease of liver cirrhosis (LC) (accounts for 80%-90%) in developed country, and also is the primary cause which induced the young adults to die, LC is normal person's 6.8 times in human alcoholics. Every country in Asian, although the toxic hepatitis occupies the main status, but the tendency of ALD increasing day after day along with the social economy condition improved and the living standard enhancemented. Especially to be worth to pay attention to is that the alcoholic liver harm may increase the susceptivity of organism to HBV and HCV; Otherwise, the chronic toxic hepatitis also can cause the sensitivity markup in patients to the ethyl alcohol, thus the alcoholism and the chronic hepatitis aggravated easily. It is said that if drinking continuously, which may activate each kind of pathogenesis and the carcinogenic factor in HBsAg carrier, and easy to urge liver cirrhosis and liver cancer occurrence and the development.Our country is the liquor culture country with long history, the intemperant has existed since ancient times, adds the recent years, whoopee water consumption rising year by year in our country along with society's development, long-term massive drinking increased unceasingly, the alcoholic liver disease patient also assumed the tendency which increased gradually, at present oneself after becomes is only inferior to the toxic hepatitis second big disease of the liver cause of disease. Therefore ALD has gradually become the topic which in the chronic disease of the liver more and more is worth taking, therefore has the necessity to make the further understanding and the thorough discussion.It is still lacking the large-scale epidemiology investigation in our country at present. The alcoholic liver disease is in the Western country liver cirrhosis main pathogenesis factor, the 60's once estimated the world dies every year of liver cirrhosis are least 310,000 people, but mostly number system because the ethyl alcohol causes. According to the estimation, the alcoholism for the cause of death took liver cirrhosis in Europe is 42%, Americas 66%, but Asia only accounts for 11%.In 1972 the World Health Organization counted, liver cirrhosis caused the mortality rate, Finland was 7.5/100,000, but France was 57.2/100,000, with this corresponding, the various countries each human of alcohol-to-oil ratio respectively was 5.1 and 16.8L, obviously the two correlation. The cardiovascular disease result mortality rate drops 2% in the American during 1950 -1974 years, but dies of liver cirrhosis rises to 71.7%. Statistics have indicated, the 80's US liver cirrhosis prevalence rate is 360/100,000 populations, in which 40%-90% for the ethyl alcohol relevant disease of the liver, in every 100,000 populations the alcoholic liver cirrhosis mortality rate was 4.40 to the 90's, the American cardiovascular disease mortality rate dropped 23%, but the alcoholic disease of the liver mortality rate dropped then 2%-3%.In our country ethyl alcohol took liver cirrhosis the cause of disease is approximately 5%-11%.But some people estimated, 90's alcoholic disease of the liver disease incidence rate 80's before increased 30 times approximately.The disease of the liver occurrence with drinks wine the quantity to have the close relation, the worldwide scale, in liver cirrhosis patient the ethyl alcohol gas casualty is in the majority. But in the ethyl alcohol gas casualty liver cirrhosis prevalence rate is 18% (postmortem examination material). Drinks wine the degree and drinks wine the duration and the alcoholic disease of the liver formation rate direct correlation.This article summarized the near ten year related alcoholic disease of the liver research literature, and unifies the clinical experience, applies qing kai ling injection coordination Chinese native medicine decoction dialectical treatment 96 examples of the liver alcoholic disease patients, has obtained the good curative effect.In recent years, as a result of alcoholic disease of the liver disease incidence rate ascension, regarding alcoholic disease of the liver research also and rich, in the method of treatment, usually by clearing wet, invigorating the spleen, the sparse liver, harmory the stomach, the refrigeration, removing extravasted blood primarily, and obtains certain curative effect. This article in summarizes in predecessor's findings foundation, the union clinical observation, thought the hot and damp phlegm stasis pent up the most common reason which occurs for this sickness, therefore adopts the refrigeration to dispel phlegm removing extravasted blood for the basic method of treatment, clinical is clear about the diagnosis to 96 examples the alcoholic disease of the liver patient to carry on the dialectical treatment, and simultaneously applies qing kai ling fluid coordination treatment clear, obtains the good curative effect, and prompts the Chinese medicine to have the broad prospect regarding the alcoholic disease of the liver treatment.This research altogether observes the alcoholic disease of the liver case of illness 96 examples, in which treatment group 48 examples, the control group 48 examples.Treatment group adopts qing kai ling injection togather QingReHuaShi and JieJiu decoction dialectical treatment, the control group only applies qing kai ling fluid treatment clear, the treatment course 1 month.Findings: The Chinese medicine symptom curative effect treatment group convalesces 3 examples, shows results 14 examples, effective 29 examples, invalid 2 examples, total effectiveness 95.83%; The control group convalesces 1 example, shows results 9 examples, effective 26 examples, invalid 12 examples, total effectiveness 75%. After the Ridit analysis, u=2.3754, P<0.05, two groups of comparisons have the significance difference, the treatment group curative effect surpass the control group.Around the liver function improvement aspect, the treatment group and the control group treats in each target quite is even has the extremely significance difference, explained two groups can improve patient's liver function obviously; The group compares two groups with ALT, the AST two on comparisons has and the significance difference, explained the treatment group in this two target improvements, surpasses the control group obviously. The research investigates the result to indicate that, the Chinese medicine has the good curative effect regarding the liver alcoholic disease intervention treatment.