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Clinico And Pathologic Analysis Of Cutaneous Tuberculosis In 112 Cases

Posted on:2008-02-18Degree:MasterType:Thesis
Country:ChinaCandidate:H Y LiFull Text:PDF
GTID:2144360212995674Subject:Clinical Medicine
Abstract/Summary:PDF Full Text Request
Cutaneous tuberculosis caused by MTB, is the skin lesion resulting from Bacillus tuberculosis erosion or the effects of other tuberculose focus of organs. There are misdiagnosis, missed diagnosis,bungle diagnosis due to the lack of special clinical manifestation of the cutaneous infection by Bacillus tuberculosis. In recent years, with the HIV infection widely spreading, the MTB drug resistant straincoming forth and the larger floating population, tuberculosis turns on the increasing tendency again, and so does the cutaneous tuberculosis incidence in some regions.The main two channels of the cutaneous infection by MTB are exoteric infection and personal infection. It is believed now cutaneous tuberculosis must have been connected with the exposure to the outside surroundings and the increasing opportunities of trauma and infection. The clinical classifications of cutaneous tuberculosis diversify and each clinical manifestations differs greatly. The typical clinical manifestation: the forms of the lesions diversify as in one part or some (eg: exanthema papulosum, tuberculum, plaque, ulcer, surface effusion or liquor puris, necrosis, scab and hyperplasia or atrophic scar etc), and with the color like dull red,damask,or maroon etc, ranging from the needle-sized papule to the pignut-sized or even larger tuberculum, plaque or ulcer. However, Most of the suffers get diagnosis after the evident ulceration which leads to the cicatriceseven the supervening serious results in the long run such as prickle cell carcinoma.From these, we can draw the conclusion that the masses'recognition and attention are far from enough. Sometimes the expending of the cutaneous tuberculosis will result in the disfiguration of the skin and the spread of the tuberceven, even some deaths from the disseminated infection. Hence, the earlier diagnosis, the better which is determined not only by the patients'recognition but the clinicians'attention. Cutaneous tuberculosis is of the diversified clinical forms, the hidden damages and atypia symptoms which leads to the misdiagnosis frequently. So, we should compare the different types with the different diseases to make a correct diagnosis according to the patho-organism which is the first choice method but not the only traditional way together with the advanced PCR. However, PCR method and the experimental anti-tuberculosis treatment are the important considerations as there is no clear clinical diagnosis when we can't exclude the possibility of the cutaneous tuberculosis especially when the patho-organism fails to. In some sense, the treatment of cutaneous tuberculosis is same to the other tuberculosis: on the first stage, adopt the systematic drug combination based on the drugsensitive test result for the different body's drug tolerance and the existence of some drug resistant strain.Due to the low incidence of disease, cutaneous tuberculosis has not been getting enough attention from the general public and the clinicians though it does great harm to the public health. In order toarouse the doctors'awareness, this thesis is to review 112 cases of the diagnosed cutaneous tuberculosis between Jul. 1987 and Jul. 2006 in our department of dermatology so as to synthetically analyze in the clinic pathology and other diagnosing methods according to its clinical and pathological manifestation. According to the diagnosis there're LV, TBVC, TCU, EI and PT, as well as LMDF and RT. Among the suffers of the 112, male 49, and the female 63, the proportion of is 1:1.29. The ages ranged from 2 to 68 with the mean age 34.64±14.00 years, and the number of suffers from30 to 39 is the most, which accounts for 32.14%, while the range 20-29 is the second. The longest course of 40 years with the mean of 3.18±5.94 years. 59 cases whose course is less than one year accounts for 52.68%, and the rest 53 cases share 47.32% whose is more than or equal to one year. The common LV is frequent among the female(36.51%), EI the female either and RT the male (34.69%). Occupations:peasant: 26, blue collar worker: 23,student: 19. Diseased parts: facial part (72cases), nasal part (8cases), ear (3cases), pars cervicalis (7cases), limb (18cases). Lesion size: the widest is 10×15cm2, the smallest is just needle-sized. Ulcer:11cases, cicatrices:15 cases.Clinical diagnosis rate:61.61%, misdiagnosis rate: 38.29%.The research result shows:1. Between the male and the female there is no significant difference about the incidence involving all the ages with the range 20-39 of the highest. The type LV is the most common and frequentlydiagnosed among the female same to EI while RT the male.2. The outdoor workers, (peasants, blue-collar workers) and students account for the majority (60.71%), shown mainly in facial parts (64.29%) where all the LMDF and RT occur while EI and PT in limb part.3. Clinical manifestations diversify like ulcer (9.82%) and cicatrice (13.39%) with PT the main cause for the former, while LV and the long disease course for the latter.4. Distinctive tuberculosis tuberculum by the patho-organism, of which there are 55 cases of caseous necrosis.5. The first diagnosis was misdiagnosed as 12 kinds of diseases whose rate was 38.39%, which also easily occur among other clinical classification.Conclusions:1. Enhance the awareness of the re-coming forth of cutaneous tuberculosis which will benefit the correct diagnosis and the treatment to this increasingly common dermatosis.2. Cutaneous tuberculosismust is connected with the exposure to the outside surroundings, the frequent trauma and the increasing opportunities of being wounded even infected and the clinicians should pay more attention to it for its serious dangers.3. Developing the recognition about the symptoms and features of cutaneous tuberculosisand, enhancing the diagnosis ability to better distinguish and taking early diagnosis and treatment for less scarring.4. Take the patho-organism examination as the first choice among the diagnosing methods, however, PCR method and the experimental anti-tuberculosistreatment are the important considerations with the unclear clinical diagnosis when we can't exclude the possibility of cutaneous tuberculosis.5. View the disease in its entirety, seeing cutaneous tuber culosisas one part of one's whole organism'tuberculosis infection instead of the skin only and the focus treatment is the systematic drug combination.
Keywords/Search Tags:cutaneous tuberculosis, diagnosis, polymerase chain reaction, treatment
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