The Clinical Analysis Of Patients With Antiphospholipid Syndrome Disease: A Report Of 12 Cases

Objective To investigate the clinical manifestations, laboratory examination and treatment of antiphospholipid syndrome(APS).Methods 12 patients with defined APS admitted from 2002 to 2007 were analyzed retrospectively .Results 12 patients were analyzed. Women were affected 5 times as that of men. 3 patients with primary APS and 9 patients with secondary APS. The patients with secondly APS were mainly complicated with autoimmune diseases, including 6 cases of systemic lupus erythematosus. Vascular thrombosis was presented in around 66.7% of the patients in this study. Thrombosis frequently involved the lower limb deep venous system(7 cases 41.1%), upper limbs venous system(4 cases 23.5%), neural system(3 cases 17.6%), and the abnormal pregancy rate in the 8 married women was 62.5%. Platelet defect was in 83.3% of the patients. The prevalence of antiphospholipid antibody(aCL) was 100%.Conclusion APS occurs most commonly among yong women, which is a disorder chracterized by recurrent venous or arterial thrombosis and / or fetal losses associated with positive aCL. Thrombosis frequently occurs in deep venous system, cerebral vascular system. Antiplatelet with low-dosege aspirin and long-term anticoagulation are main therapeutics.