| Radix Sophorae tonkinensis has been widely used in clinic for treatment of liver diseases in China for long history. However, the active fraction hasn't been intensively studied. In this dissertation,active fractions were isolated and investigated on acute hepatic injury rats induced by CCl4 to evaluate their live protection effects. Rats firstly received different isolated fractions of the plant for several consecutive days before injection of CCl4. Then their serums ALT and AST levels were quantified after 24h of taking in CCl4. The levels of ALT,AST significantly decreased in groups treated non-alkaloids fractions of Sophorae tonkinensis, compared with those of model group.The results suggest that fractions of non-alkaloids from Radix Sophorae tonkinensis are effective in protecting against hepatotoxicity induced by CCl4, which obviously differs from the conventional concept and encourages tofurther research on active principals. |
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