Relationship Between Decoration Pollution, MPO SNPs And Leukemia

Acute leukemia is the most frequent malignant form of cancers affecting adults especially youngsters, which constitutes about 10% of all the adult cancers. The etiology of adult acute leukemia has not been well understood, and no consistent conclusions have yet been made. Environmental and genetic factors are commonly considered to jointly result in acute leukemia. We applied epidemiological and toxicological technology from environment-gene levels, to study the relationship between decoration pollution, MPO SNPs and adult acute leukemia in this paper.1. Study on benzene series and formaldehyde pollution in indoor air of newly decorated roomsThe indoor air concentration of benzene series and formaldehyde of 17 newly decorated apartments were detected from July to December of 2005. The adverse responses of residents from the decoration were investigated by questionnaires. The results were benzene series concentration of indoor air was gone down rapidly in 2 months; meanwhile, formaldehyde concentration was gone down slowly in 6 months after decoration. There was significant difference of formaldehyde concentration between rooms of wood furniture and those of artificial wood furniture. A positive correlation was found between adverse responses of residents and the indoor air concentration of formaldehyde. It was shown that the indoor air pollution of benzene series and formaldehyde is popular after decoration, especially that of formaldehyde. The bedrooms pollution was more severity than that of living rooms; and the pollution of wood furniture rooms was more severity than that of artificial wood furniture rooms. Indoor air pollution by decoration is one of risk factors to the health of residents.2. Subchronic toxicity and genotoxicity of benzene and formaldehyde to BALB/C MiceThe benzene (50mg/kg) and formaldehyde (2mg/kg) was applied on to BALB/C mice by intraperitoneal injection, once per a day, for a month. The mice were then killed by...