To Study Difference Of Anti Platelet Drug Resistance Between Han Nationality And Uygur Nationality Patients With After PCI In Xinjiang

Objectives:We sought to compare and analysis difference of Thrombelastogram monitoring antiplatelet drug resistance between Han nationality and Uygur nationality patients with after PCI in Xinjiang,Relationship between antiplatelet drug resistance and major adverse cardiovascular events.Methods:Continuous selection from August,2015 to Oct,2016,who to be in The People’s Hospital General of XinJiang Uygur Autonomous Region to accept the coronary artery interventional therapy,the patients of Han people(60 cases)and Uygur(68 cases)to amount to 128 cases to study and research.According to different nationality,they were divided into twogroups: Uyghur group(68 cases)and Han group(60 cases).All patients in the after PCI test Thrombelastogram,the detection rate of AA induced platelet inhibition,ADP induced platelet inhibition rate,blood clot strength induced by ADP(MAADP).To analyze whether there is a difference in platelet inhibition rate among different ethnic groups.All patients were followed up for 3 months after discharge,and the incidence of major adverse cardiovascular events(MACE)was recorded.To analysis Relationship between platelet inhibition rate and major adverse cardiovascular events.Results:There was no significant difference(P>0.05)between the two groups in age,gender,personal history,and history of disease.A total of 22 cases(17.19%)occurred in patients with clopidogrel resistance,including 6 cases of Han patients(10%),16 cases of Uygur patients(23.53%),the difference was statistically significant(P<0.05).A total of 13 cases(10.16%)occurred in patients with aspirin resistance,including 6 cases of Han patients(10%),7cases of Uygur patients(10.29%),the difference was not statistically significant(P>0.05).A total of 16 patients(12.50%)MAADP anomaly,which is of the Han nationality in 3 patients(5%)with abnormal MAADP,Uygur patients of 13 cases(19.12%)of abnormal MAADP,the difference was statistically significant(p<0.05).In the 3 months of follow-up,a total of 14 patients with major adverse cardiovascular events(MACE),the MACE incident response to clopidogrel in patients with normal in 8 cases,the incidence rate was 7.55%,while clopidogrel resistance in patients with MACE events happened in 6 cases,the incidence rate was 27.27%,the difference was statistically significant(P<0.05).11 patients of MACE events in the aspirin reaction is normal,the MACE event rate was 9.57%,there were 3 cases of MACE 13 cases of aspirin resistance in patients,the incidence rate was 23.08%,the difference was not statistically significant(P>0.05).The incidence of MACE events in patients with normal MAADP was 9,with an incidence rate of 8.04%,MAADP abnormalities in patients with MACE events occurred in 5 patients,the incidence was 31.25%,the difference was statistically significant(P<0.05).Conclusion: There was no difference in aspirin resistance between Uygur and Han patients after PCI,but there was a difference in clopidogrel resistance.The incidence of clopidogrel resistance in Uygur patients was higher than that in Han patients.Aspirin resistance after PCI did not increase the incidence of MACE events,whereas clopidogrel resistance increased the incidence of MACE events.After PCI patients with MAADP≥50mm increased MACE incidence.