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Protective Effects Of Gross Saponins Of Tribulus Terrestris On Experimental Intracerebral Hemorrhage In Rats

Posted on:2007-07-07Degree:MasterType:Thesis
Country:ChinaCandidate:L B LiFull Text:PDF
GTID:2144360212959420Subject:Pharmacology
Abstract/Summary:PDF Full Text Request
Cerebrovascular disease is a common disease and frequently occurring that severely threatens human health and longevity. Recently, cerebrovascular disease is one of the three main causes for adult death. Intracerebral hemorrhage (ICH) is a devastating clinical condition,the incidence of mobidity and mortality from ICH remains high.Currently, there is no medical therapy available for these patientsexcept neurosurgical evacuation of the hematoma. Patients whosurvive ICH are usually severely disabled. The mechanisms of braininjury after ICH are not fully understood. The study of ICH in the rat attracted increasing attention.Tribulus terrestris refers to the dry, ripe fruit of the plant caltrop. Its main chemical ingredients are saponins, ketone, alkaloid. The gross saponins of Tribulus terrestris(GSTT) was one of the effective group ingredients which was exracted from the whole plant of caltrop. It is a mixture of over 10 kinds of saponins, mainly steroid saponins. It mainly includes furan-strol and spiral-strol. It is a powder and dissolvable in water. Domestic research materials showed that GSTT had the effect of lowering blood pressure and stimulating antihypoxia, sheeting blood vessels, lowering cholesterol, inhibiting fat deposition on arteries, myocardium and liver. It also inhibited atherosclerotic occurrence and development. It had positive effects on brain ishemia, lowering...
Keywords/Search Tags:Intracerebral
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