Expression Of MCM5 And Its Clinical Significance In Gastric Carcinoma

Objective Minichromosome maintenance proteins (MCMs) are a group of proteins closely related with the DNA replication, consisting of MCM2, MCM3, MCM4(Cdc21), MCM5(Cdc46), MCM6(Mis5) and MCM7(Cdc47). MCM proteins are important member of replication licensing factor (RLF), which indicate the start of the initiation of DNA replication bonding with the chromatin before the initiation of DNA replication. MCM proteins are only present within the nucleus throughout the cell cycle, the mRNA levels of MCM proteins in the normal cells changes with the cell cycle. Its expression reach to peak in G1/S conversion, and in GO phase, differentiation or apolexis, the mRNA levels of MCM proteins declined to so little that can not be detected. MCM proteins express in high level in proliferating cells, and in low level or never in GO phase cells or differentiated cells, so MCM proteins may be a special marker of proliferating cells. tumour cells compared with normal cells display a quick proliferation capacity on the functional status besides the characteristics of morphology. Therefore, MCM proteins can be used in tumour research. MCM5, as a member of the MCM proteins, can response MCM proteins level. A series of studies of MCM5 expression including esophagus, cervix and bladder show that MCM5 is a good markers for cell proliferation, and is a potential value marker for tumors. But it has not reported systematically to the study about MCM5 expression and clinical significance in gastric tissue. Through the preliminary study about MCM5 in gastric carcinoma, we hope the experiment can be played a certain role of reference on the clinical diagnosis, classification,...