Clinical Evaluation Of Acute Severe Brain Impairment And The Change And Significance Of ADM,CGRP And S-100 Protien In Plasma

Objective: To investigate the methods for evaluating acute severe brain impairment accurately and objectively; To investigate the change of adrenomedullin(ADM) and calcitonin gene-related peptide(CGRP) and S-100 protien concentrations in plasma from patients with acute severe brain impairment and their significance, to find the correlation with the brain impairment and the clinical outcome.Methods: Using clinical examinations and laboratory methods(such as EEG, BEAP, SLSEP and TCD), 35 cases with acute severe brain impairment were evaluated, and plasma at the first three days of these patients were collected; At the same time, clinical information and plasma of 20 normal controls were collected. Plasma concentrations of ADM and CGRP in patients with acute severe brain impairment (BF, 35 cases) at the first three days and 20 normal controls were measured by RIA; plasma concentrations of S-100 protien in patients with acute severe brain impairment at the first three days (BF, 35 cases) and 20 normal controls were measured by ELISA. At the same time, the correlation between the plasma levels of ADM, CGRP and S-100 protien at day 1 in patients with the serious of brain impairment and the clinical outcome was analyzed.Results: (1). The main cause of acute severe brain impairment of the 35 cases was hypoxemia and ischemia of the brain induced by all kinds of reasons. In 35 cases , 20 cases were determined as brain death; 8 cases were determined as...