| Background :ulcerative colitis is an agnogenic chronic non-specific inflammatory bowel disease of rectum and colonic .its disease incidence approximately 5-12/10 ten thousand in Europe and America .Our country always consided that this disease have a low incidence, but the hospitalized patients with UC inceased yearly in recent years,the patients of literature reporte furthermore increased yearly.All these hint that inflammatory bowel disease always became a principal disease of intestinal tract. but many medical workers have a insufficient recognition to this disease in clinic. the diagnosis criteria is not strict ,the therapeutic regimen is not standard. This study have three part , the first , A retrospective study of the data of 386 cases of UC in our hospitals from 1995 to 2006 .the second ,comparative studies on the therapeutic effects of 5-ASA and salicylazosulfapyridine enema on active ulcerative colitis .the third ,follow-up the prophylactic effect of probiotic,mesalazine and the combination of the two drugs .Objective :1.To analyze the characteristics of hospitaled patients with ulcerative colitis。2.To compare the therapeutic effect of5-ASA and salicylazosulfapyridine enema on active ulcerative colitis.3.To compare the prophylactic effect of probiotic,5-ASA and the combination of the two drugs.Methods: the first part :three hundreds and eighty-six UC patients identified at our hospital from1995 to 2006 were studied. Demographic and clinical data were collected and analyzed. The second part :126 patients were divided into three groups .one group were treated with 5-ASA enema , the other treated with SASP enema ,the last group treated with 5-ASA Po. The drugs were administrated for 4 weeks. The third part :Ninety-six patients with ulcerative colitis in remission stage were enroll randomized three groups .one group was treated with 5-ASA, The other was treated with probiotics ,the last was treated with the two drugs.Results :1.The endoscopic diagnosed UC increased yearly in the recent years.215 men,171women,male/female ratio 1.25:1.The peak age was 30-49years old.Among these UC patients ,20.48% was proctitis ,26.94 was proctosigmoiditis,19.95% was colitis of left-colon and7.51% was pan-colitis. Most of the mild severity was proctitis and proctosigmoiditis Most of the severe UC was pan-colitis. The course of disease of was 12h-40 years, the mean course was 34.76±12.10 month .The majoy symptom were diarrhea ,abdominal pain and bloody stool. Most of the hospitalzed UC patients revealed mild or moderate severity. The mainstay for UC treatment was still 5-aminosalicylate (5-ASA) agents and glucocorticoids ,combination probiotic and protective agent of intestinal mucosa.the drug of enema mainly was 5-aminosalicylate and glucocorticoids the total effective rate was 90.16%, The remission rate by medical reached 92.22%.Only 2.85% under went surgical intervention. Only 0.52% canceration rate,2.The effect of 5-ASA po. Add 5-ASA enema is advantage than the purely 5-ASA po. ,The effect of 5-ASA enema than the SASP enema ,the effect of 5-ASA purely po is no significant different to the SASP enema. The side effect of the three groups no significant different .3.To the groups with Mesalazine ,the recurrence rate is 34.2% .the groups with prebiotic ,the recurrence is 36.7%,the recurrence of the groups with combination of the two drugs is 14.29%,The first group and the second group are no significant deviation ,The third group have significant deviation to the later two groups. The recurrence of the third group relation to the intestinal infection is little to the later two groups.Discussion: This groups of UC have the following clinical characteristic : During the past 12 years ,the incidence of UC was increased. The peak age was 30-49years old., Ten years later than its morbidity of abroad. The course of disease is shorter than its happen in the abroad. In all cases mainly was chronic relapsing and first onset.. Among these UC patients , 19.95% was proctitis ,26.94 %was proctosigmoiditis, 24.61% was colitis of left-colon and7.51% was pan-colitis. Most of the mild severity was proctitis and proctosigmoiditis Most of the severe UC was pan-colitis.. In all cases have rare extraintestinal manifestations and complications. Mainly diagnosis method were endoscopy followed by histology and radiology. Most of the hospitalzed UC patients revealed mild or moderate severity. The mainstay for UC treatment was still 5-aminosalicylate (5-ASA) agents and glucocorticoids , combination probiotic and protective agent of intestinal mucosa. the drug of enema maily was 5-aminosalicylate and glucocorticoids the total effective rate was 90.16%, The remission rate by medical reached 92.22%. operability,mortality and canceration rate is shorter than the abroad.Have many study to the nosogenesis of UC in the nowdays.It is believe that the factor mainly related the infection factor ,genetic predisposition ,dysimmunity .though the three factor can become the object of interupture, but major concentrate in the infection factor and Dysimmunity .SASP,5-ASA and glucocorticoids just interrupt the genesis and development of UC from the three factor. In resent years advocate to enema treatment to the proctitis and proctosigmoiditis .The medicine chiefly have SASP, 5-ASA, glucocorticoids and herb .The appearance of the new dosage of 5-ASA provide the new perspective for the therapy. due to the expensive price ,restrict the utilize of these new drugs. By the usage to the traditional drugs enema with SASP and 5-ASA,decrease the lose of the drugs in the small intestine, elevate the density in the colon, reduce the by-effect, elevate the effect.It has been demonstrate that the intestinal flora plays an important role in the phthogenesis of UC. Probiotics can probably prevent and treat UC effectively through the mechanism by mainly biology rivalry,modulating mucosal immune activity and epithelial harrer function as a hiological antagonist , Probiotic can increase the activity of macrohagus and lymphocyte by stimulated them and enhance the activity of the immune of intestinal mucosa .which has already been proven by clinical trials for maintaining UC treatment.Many research team already evaluation the effect of the non-pathogenicity intestinal strain to UC treatment. CUI report that give the UC patients with probiotic ,the contents of lactobacilli and bacill bifidus in the stool are increase than the normal person .The contents of is miyarisan ,it overcome the low survival rate on.It also can rivalry the harmful bacterium ,promote the growth of the benefical .bacterium ,adjust the balance of the baceriun of intestinal tract.furthermore butanoic acid is important nutritive substance of cytothesis and prothetic ,keep the complete of barricade of intestinal mucosal ,it can also secrete the olitosaccharidenase that can promote the growth of the benefical bacteric,regulation the host genetic expression ,recover the immunologic function,chemical barrier of intestinal tract and biologic barrier.By cure the paracmasia patients of UC with miyarisan,we found that the curative effect to the paracmasia UC patients with miyarisan is equacal to the mezalazine ,and no the apparente side effect,so it is a recommendable drug to the paracmasia patients of UC ,and the combination of these two drugs can promote the currative effect .but we should carefully evaluation the clinical experiment by large sample ,multicentre double-blind,placebo experiment.Conclusion:1.This groups of UC have the following clinical characteristic :During the past 12 years ,the incidence of UC was increased. The peak age was 30-49years old.The course of disease is shorter than its happen in the abroad. In all cases maily was chronic relapsing and first onset, acute fulminant type was few. Among UC patients ,maily was proctitis,proctosigmoiditis and colitis of left-colon .Most of the mild severity was proctitis and proctosigmoiditis Most of the severe UC was pan-colitis..In all cases have rare extraintestinal manifestations and complications. Mainly diagnosis method were endoscopy followed by histology and radiology. Most of the hospitalzed UC patients revealed mild or moderate severity. The mainstay for UC treatment was still 5-aminosalicylate (5-ASA) agents and glucocorticoids ,combination probiotic and protective agent of intestinal mucosa. To the proctitis and proctosigmoiditis ,enema is a good cure approach.the drug of enema maily was 5-aminosalicylate and glucocorticoids the total effective rate was 90.16%, The remission rate by medical reached 92.22%. operability,mortality and canceration rate is shorter than the abroad.2.It have a good effect that enema with sulfasalazine and 5-ASA to the active stage patients of UC, further more ,the effect of the 5-ASA is surpass the sulfasalazine .It decrease loss of the drug and diminish the side effect.3. the curative effect to the paracmasia UC patients with miyarisan is equacal to the mezalazine ,and no the apparente side effect,and the combination of these two drugs can promote the currative effect.
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