Analysis Of Biliary Germiculture And Antibiotic Susceptibility Test In The Biliary Tract Infection Patients And Selection Antibiotic

Background and objectiveBiliary tract infection is a common disease in clinical practice. To survey the biliary pathogenic bacteria and their resistance to antibiotics in the biliary tract infection patients, is important to selection of antibiotics, especially in experiential treatment or pre-operative anti-inflammatory medication or before the result of drug susceptibility come out. However, the experiential medication is always based on the results of biliary culture and drug susceptibility examination in biliary infect patients in recent years. So it's valuable to analyze the results of bacteria in our hospital or neighborhood as the guidance to selecting antibiotics. This study evaluate the positive results of bile culture and drug susceptibility in recent 2 years, and to instruct rational application of antibiotics clinically.Material and methodsThe data of 326 strains of pathogen found in the positive bile culture from January 2004 to December 2005 and their sensitivity to antibiotics were statistically analyzed by WHONET 5.3.ResultsTotally 326 strains were identified including 176 gram negative strains (54%, 176/326) and 139 gram positive strains(42.6%, 139/326), 11 fungal strains(3.4%, 11/326). The most common pathogenic bacteria were Escherichia coli (23.6%, 77/326), Enterococcus faecium(12.6%, 41/326), Enterococcus faecalis(10.4%, 34/326), Staphylococcus(10.1%, 33/326), and Klebsiella pneumoniae(6.7%, 22/326). The results of drug susceptibility showed that the resistant rates of gram negative strains to Imipenem was the lowest(12%) Among Meropenem(12.1%), Cefoperazone and Sulbactam(16.6%) and Amikacin(19.1%), but to Ampicillin, Piperaclin, Ampicillin and Sulbactam, Cefazolin, Ciprofloxacin was high. None of gram positive strains resisted to vancongcin and Teicoplanin, and the rates to Chloromycetin, Nitrofurantoin, Fosfomycin respectively was 12%, 15.6%, 18.2%.ConclusionsGram negative strains remain features prominently in the Biliary tract infection, but gram positive strains is rising. The resistant rates of common antibiotics is increasing, so it's important to use them properly.