A Primary Study On Antimicrobial And Antitumor Activities Of Microorganisms Isolated From Deep Sea In The Tropical Pacific Ocean

There is different metabolism and recovery system between marine microorganisms and terrestrial ones, because of sea hold unique envir -onment. bio-active substances extracted from marine microorganisms have unique chemical structure and physiological function, especially, biological activities are mainly focused in the area of antibiotic,anticancer and antiviral properties. Marine microorganisms for potential pharmaceutical resources have formed a hot field for searching for novel and specific drugs since past years.The research of marine micro-organisms resources is mainly focused in offing at present. We pay Less attention about open sea and deep-sea because of the restriction of sampling and culturing condition. In this thesis we collected samples of sediments,waters and organisms fauna from the"warm pool"region of west pacific ocean,middle pacific ocean and the"multi-metal nodules"region and covering"hydrothermal vents"of east pacific ocean., isolated deep-sea microorganisms, screened bio- active strains with antimicrobial and antitumor activities, and further investigated the physiological and bio-chemical characteristics of act- ive microbes and finished their molecular identification. We will provide some basic information and some bioactive strains for the discovery of deep-sea microbial drug.20 bioactive microbial strains, which showed the capacities of anti-microbes and/or anti-tumors, were obtained, being screened, by means of 8 screening models and a paper-dish technique, from a total of 475 strains consisting of bacteria, yeasts and molds isolated from the samples of fishes, sea waters and sediments taken in the tropical Pacific Ocean.