The Effect Of TiaoZhiJi Solubal On HA, LN, PCⅢ And TNF-α Of The Hepatic Fibrosis Rat

Objective To establish hepatic fibrosis pattern by composite factor, by observing the detection of TiaoZhiJi Solubal's(TZJ) influence on hexadecenoic acid(HA), precollagenⅢ(PCⅢ), tumor necrosis factor-α(TNF-α), hepatic tissue pathology and some Liver function biochemical indicators, investigate utility and validity of TZJ in the prevention of hepatic fibrosis and provide theory for further study.Methods Forty eight male Wistar were divided into four groups randomly: the normal group, model group, the Essential N/Essentiale Forte N(ESF) group and the TZJ group. Emulsion and carbon tetrachloride(CCl4) was used to induce hepatic fibrosis pattern in the rat's liver. Compared with ESF group, detection the change of hepatic function biochemical indicator, such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), and HA, PCIII and TNF- α in serum, and the histopathology of liver.Results All indexes of the model group are higher than that from normal group's. TJZ does defend the liver from tissue damage and the fat destruction. It does reduce the indexes of ALT, AST, HA, PCIII obviously in serum. It can control the release the TNF- α.Conclusion The function mechanism of the TZJ is to prevent the hepatic fibrosis:1. Reduce the indexes of AST and ALT in serum and protect the liver.2. Restrain the generation of collogen and proteoglycan in...