Application Study Of Diffusion Weighted MR In Assessing The Outcome Of Interventional Treatment On Hepatic Carcinoma Patients

Objective: Use MR SE-EPI-DWI to evaluate the value of diffusion weighted magnetic resonance imaging in assessing the outcome of interventional treatment on hepatic carcinoma patients.Materials and method: 24 healthy persons and 26 patients were recruited, all the subjects underwent first routine T₁-weighted and T₂-weighted imaging of the whole liver and then diffusion-weighted MR imaging by using of 2 different b factors under breath-hold. Signal intensity was measured and ADC, CNR and the signal value in T2-weighted imaging were calculated. Patients were scanned two times that 2 days before and the 5 or 7 days after the operation.Result: 7 of 50 cases were excluded for poor images. So there were, in fact, 43 cases, among whom were 20 healthy people and 23 patients. Patients were followed-up for 3 months after operation and classified to survival group(15 case) and death group(8 case).The mean ADCs in healthy people were 1.938×10-3mm²/s±0.375(b=300 s/mm²),1.602×10-3mm²/s±0.313(b=500s/mm²) in liver. Compare the ADC value of lesion after operation there was significant difference between survival group and death group (t test p = 0.022,b=300s/mm²)(t test p = 0.007,b=500s/mm²); compare the lesion/liver ratio after operation there was significant difference between survival group and death group (t'test p=0.032,b=500s/mm²) and no significant difference when b=300s/mm²; compare the ADC value ratio of lesion after and before operation there was significant difference between survival group and death group (t'test p=0.003,b=300 s/mm²)(t'test p=0.007,b=500s/mm²).Analyse the liver, spondyle, erector spinal muscles signal intensity of T2-weighted imaging,significant difference was found between survival group and death group in lesion-liver ratio (t'test p=0.017) and lesion-spondyle (t'test p=0.02) ratio after and before operation.