Study Of Effect Of Prostaglandin PGE₁ On Peri-Operative Pulmonary Hypertension

Objective: Hypertension is one of the common and serious complications of the congenital heart disease(CHD) and the rheumatic heart disease(RHD). with the basic treatment of prostaglandin E₁ onpulmonary hypertension, this research is mainly to explore the time-effect relationship, the dose-effect relationship of PGE₁ the similarities and differences of reaction of PGE₁ on patients with congenital heart disease and rheumatic heart disease as well as its special effect on the hypertension crisis.Methods: First, twenty-nine patients associated with pulmonary hypertension were divided into two groups: (1) The congenital heart disease patients (n=18).(2) The rheumatic heart disease patients (n=11).Swan-Ganz float catheter was put into pulmonary artery through right jugular just after anaesthesia, following indexes were examined both before and after Using PGE₁(20ng/kg/min) so that we studied the effect on pulmonary hypertension: mean arterial pressure (mAP), mean pulmonary arterial pressure (mPAP), mean pulmonary capillary wedge pressure (mPCWP), cardiac index (CI), heart rate (HR),arterial oxygen pressure(PO₂),arterial carbon dioxide...