Expression Of FAS, Ki₆7 In Oral Squamous Cell Carcinoma

Fatty acid synthase (FAS) is the key enzyme in intracellular fatty acid biosynthesis, FAS overexpression has been detected in some human malignant tumors, such as cancers of breast, prostate, endometrium and colorectum.Proliferating antigen Ki₆7 is an important biological marker in cell proliferation,and many researches suggest a possible relationship between Ki₆7 expression and tumor virulence.Objective To investigate the relationship between the expression of fatty acid synthase(FAS),proliferation cell nuclear antigen(Ki₆7) and the clinicopathological parameters in human OSCC,to investigate roles of expression in neoplasia and development of cancers, and find new way of treatment.Methods The expression of FAS,Ki₆7 were detected by immuno- histochemistry method in tumor tissues of 66 patients with...