Studies On The Anti-inflammatory Activities And Modulatory Effects On Immune Function Of Ampelopsis Grossedentata

Ampelopsis grossedentata (Hand.-Mazz) W.T.Wang grows wild in the southern region of China. Healthy tea has been made from the sterms and leaves for treating common colds and pyretic fever, inflammatory, pain-swelling of pharynx and larynx as well as jaundice hepatitis,with a long history of several hundred years among the Yao people in Guangxi and Hunan provinces. It contains a very high yield of dihydroflavonol. The anti-inflammatory activities, modulatory effects on immune function of AGE and its mechanism are studied in this paper. And firstly, using a method of serum pharmacology, the anti-inflammatory effect and immunological activity of AGE were studied .The anti-inflammatory effects of AGEOur study on the activity of the extract of this healthy tea showed that AGE significant anti-inflammatory activity was found in various experimental animal models. The data showed that AGE (5, 10g/kg, p.o., for 5d) markedly inhibited hindpaw edema induced by carrageenin in rats, ear edema induced by dimethylbenzene, and increased capillary permeability in the mouse abdominal cavity induced by acetic acid. Moreover, the chemotaxis of WBC induced by CMC, the weight of cotton-pellet grahuloma in mice and the weight of croton oil-gas cyst in rats are suppressed markedly. AGE (5, 10g/kg, p.o., for 5d) significant suppressed ear edema induced by dimethylbenzene in adrenalectomyized mice. Apart from these actions, AGE (5, 10g/kg, p.o., 5d) markedly inhibited the levels of MDA, PGE₂, Histamine and 5-HT in exudates of paw edema induced by carrageenan in rats. The present study provided evidence that AGE has significant anti-inflammatory activities, suggesting the benefit action of Ampelopsis grossedentata for health.The modulatory effects of AGE on the immune functionThe results showed that AGE ( 0.3, 0.6, 1.2, 2.5, 5g/kg, p.o., for 15d) markedly...