Study On An Animal Experimental Rat Model Of Severe Heatstroke Induced By A Combination Of Hyperthermia And Lipopolysaccharide

Study background: Heat stroke is a life-threatening heat-related illness characterized by a rapidly increasing core body temperature and central nervous system abnormalities, can cause shock, acute lung injury (ALI) / acute respiratory distress syndrome (ARDS), and multiple organ dysfunction syndrome (MODS). The mortality and morbidity of heatstroke may increase with global warming and the predicted worldwide increase in the frequency and intensity of heat waves. The mediation of metabolic changes and tissue damage is not fully understood. Recent evidence has shown that gut derived endotoxin enters the circulation during heat stress and mediates the hemodynamic disturbance and thus contributes to the mortality seen in this illness.Objective: To establish an experimental animal model for severe heatstroke induced by a combination of hyperthermia and lipopolysaccharide (LPS), to characterize the systemic inflammatory response syndrome (SIRS) pathway in heatstroke and MODS, to allow further study of the intensive care and pathogenesis of severe heatstroke on targeting decrease the clinical course and improvement outcome.