Studies On The Neuroprotective Effects Of Puerarin Derivatives And Its Mechanisms In Rats From Cerebral Ischemia And Reperfusion

Ischemic cerebrovascular disease is one of the commonest diseases with high mortality and disability rate in clinical practice. Cerebral ischemia can reduce the blood flow of focal brain tissue, which results in functional impairment and morphological destruction. Although it recanalizes the clogged blood vessel and resumes the blood supply of ischemic tissue, reperfusion can induce cerebral ischemia reperfusion injury and aggravate the primary pathological changes. In clinical practice, the recanalization of blood vessel produced by rt-PA which is thrombolitic drug and the rate of spontaneous recanalization up to 50% can both lead to cerebral ischemia reperfusion injury. The existing neuroprotective drugs that antagonize cerebral ischemia reperfusion injury are not effective and have many side effects. Except that the free radical scavenger which has been on sale in Japan has been clinically verified, other drugs still need further clinical verification. This prompted us to seek for safe and effective neuroprotective compounds.