Research Of NNOS'Change And Meaning After Myocardial Infarction In The Rat

AMI is a main reason of dead in cardiopulmonary system. Dead for AMI is about 50﹪for all heart disease, about 40﹪for congestive heart failure. Because AMI is very important and frequently happen in clinical, the research for its reason and prevention been more and more attached. Furthermore, research for a system of change of factor after myocardial infarction is becoe hot. NO as a important factor, have much physiology function such as regulating immunity, transmit nerve act, regulate blood pressure, restrain blood platelet condense and so on. NO is producted for L-Arg and oxygen, NOS is its important enzyme. NOS be divided three types, induced NO synthase(iNOS), endothelial NO synthase(eNOS) and Neuronal NO synthase(nNOS). NO will increase when any NOS increased. Report of expression and meaning of iNOS and eNOS in cardiopulmonary system are very much, nNOS have used to research for nerve system, recently, some experiments have indicated thant nNOS expressioned in cardiopulmonary system have more important meanings. Its meaning is when NOS increased, NO is increase too, it can reduce relevant time rat's bmp after AMI. Moreover, some experiment showed that nNOS's expression increased after rat AMI can through some mechanism reduce to PGE2's expression, protect heart after AMI. Although reports about these are few and much mechanism is unknow , but function of nNOS in cardiopulmonary system been more and more attached. Therefore, my experiment use model of rat AMI, observe nNOS's expression after rat myocardial infarction, appraise its change influence for rat's bmp and PGE2's expression and its meaning.