Experimental Study Of Magnesium Sulfate On Cerebral Vasospasm Following Subarachnoid Hemorrhage

Objective: Cerebral vasospasm(CVS) following subarachnoid hemorrhage(SAH) is a major cause of high mortality and morbidity for those experiencing the rupture of intracranial aneurysm, and it often induces ischemic neurological deficits. But its true mechanism and secondary impairment still remain unclear, and there is no very effective method to prevent and treat CVS. Lots of clinical and experimental studies have shown that "calcium over loading" is one of an important cause of CVS following SAH, and more and more studies have focused on the natural antagon of calcium - magnesium, with the effect of vessels-dilation and neuroprotection. In the present study we assessed the anti-CVS effect of magnesium sulfate in rabbit CVS model after we observed the behavior changes, morphological changes and ultrastructural changes of basilar arteries.Methods: CVS model was established by using "double subrachnoid hemorrhage" which injecting arterial blood twice through the citerna magna 48 hours apart, 2 milliliter each time. Thirty rabbits were equally randomized to three groups as follows: â‘ SAH group (n=10): SAH was produced by injecting 2ml of autogenous arterial blood into subarachnoid space through cisterna magna twice. â‘¡Saline control group (n=10): rabbits were injected twice with 2ml of physiological...