～1H-MRS Study On Migraine

Objective: The pathogenesis of migraine is still unclear, though it is a so common disease. ~1H-MRS is a new technique that can detect the alterations of some metabolites in vivo. Our aim was to study if there are metabolites concentration change in the patients of migraine without aura. And if we can detect the metabolites change, maybe we can find a new diagnostic method for this disease, for we usually diagnose migraine from the history of illness and the symptoms. Also it can be used as a tool for effect analysis of the treatment.Materials and methods: 15 migraineurs without aura and 9 normal controls were collected in this study. A 3.0T MR(magnetic resonance) scanner was used to get the ~1H-MRS. We used multi-voxel method to get the spectrum of both cerebellar hemispheres, both occipital lobes and both thalami. Using the method of relative quantification, we compared the NAA/Cho, NAA/Cr, Cho/Cr of both sides and between patients and controls.Results: The patients was divided to two subgroups: LH(patients who had headache mainly in the left side) and RH(patients who had headache chiefly in the right). In our study of normal controls, we found there were no differences between the bilateral hemispheres of cerebellum, occipital lobes and thalami. We found the value of NAA/Cho in cerebellum was the lowest, and in occipital lobes got the highest; the value of NAA/Cr also got the lowest value in the cerebellum, but the Cho/Cr got the highest value in the cerebellum. NAA/Cr of cerebellum(average value of both sides) of patients was found lower compared to the controls. When comparing...