The Protective Effect Of Thyroid Hormone In Rats With Obstructive Jaundice

Objective: To investigate the degree of injury of intestinal mucosal barrier, the relationship between metabolic abnormalities of exogenous hormone and intestinal barrier dysfunction, the protective effect of thyroid hormone (TH) in rats with obstructive jaundice. Methods: Thirty-two Wistar rats were randomly divided into 3 groups: sham group(SO) plus normal saline(NS) group(n=12), bile duct-ligation(BDL)group plus normal saline(NS) group (n=9), bile duct-ligation(BDL)group plus thyroid hormone(TH) group (n=11). Serum FT₃,FT₄ and rT₃ level, and intestinal activities of diamine oxidase(DAO), plasma endotoxin level in portal vein and injury of intestinal mucosal grade were were examined on 14th days. Results: In comparison with sham group plus normal saline group ,serum FT₃,FT₄ and rT₃ level, and intestinal activities of diamine oxidase(DAO), plasma endotoxin level in portal vein increased and injury of intestinal mucosal grade in BDL group were increased or decreased on 14th days (P <0.01). In comparison with BDL plus NS group serum FT3,FT4 and rT3 level, and intestinal activities of DAO, plasma endotoxin level in portal vein and injury of intestinal mucosal grade in BDL group were increased or decreased on 14th day (P <0.01) ,but comparison with SO plus NS group the BDL plus TH group showed no significantly difference (P >0.05) . Conclusions: Along with injury of intestinal mucosal barrier of obstructive jaundice, the level of serum thyroid hormone decreased and the level of plasma endotoxin increased, and intestinal activities of DAO decreased. The supplement of additional TH can protect intestinal mucosal barrier and alleviate injury of intestinal mucosal barrier in rats with obstructive jaundice.