| Objective: To analyze the frequency of platelet glycoprotein Ia Gene 807 nt genotypes in acute myocardial infarction (AMI) group and control group. To investigate whether the GP Ia gene 807nt polymorphisms were associated with the risk of AMI. Subject and Method: Thirty two patients suffered from acute myocardial infarction within one week, as defined by World Health Organization criteria. And thirty two control subjects were recruited. The participators in control group had no histories of coronary heart disease, ischemic stroke and peripheral arterial disease. The GP Ia gene 807nt polymorphism were detected by polymerase chair reaction amplication of fragments of DNA by using specific oligonucleotide primers in a thermal cycler. Restricted DNA products were then separated by using 2% agarose gel electrophoresis and visuslized by UV light. Interactions between these changes and other factors were analyzed with SPSS statistical software 11.5. Result: (1) There were significant differences in GP Ia gene 807nt allele distributions between AMI and in control groups, the frequence of GP Ia gene 807ntT allele were higher in AMI group than control group. (2) There were significant differences in GP Ia gene 807nt genotype distributions between AMI and control groups, the frequence of GP Ia gene 807nt TT +TC genotypes in AMI group were higher than that in control group. (3) There were no significant differences in hypertension and diabates groups in two GP Ia gene 807nt genotypes. (4) There were no significant differences in free plasma blood sugar, triglyceride levels in two GP Ia gene 807nt genotypes. (5) Levels of blood triglyceride were higher in patients than that in control subjects. Conclusion: (1) GP Ia gene 807nt T genotype is a genetic risk factor of acute myocardial infarction. (2)GP Ia gene 807nt polymorphisms have no associations with hypertension and diabetes. (3) GP Ia gene 807nt polymorphisms...
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